Dioleoylmethotrexate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597199

CAS#: 141456-07-7

Description: Dioleoylmethotrexate is an antineoplastic drug.

Chemical Structure

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Dioleoylmethotrexate
CAS# 141456-07-7
Instruction

Theoretical Analysis

MedKoo Cat#: 597199
Name: Dioleoylmethotrexate
CAS#: 141456-07-7
Chemical Formula: C56H86N8O7
Exact Mass: 982.66
Molecular Weight: 983.350
Elemental Analysis: C, 68.40; H, 8.82; N, 11.40; O, 11.39

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Dioleoylmethotrexate;

IUPAC/Chemical Name: L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, dianhydride with 9-octadecenoic acid, (Z,Z)-

InChi Key: CEXMEEOLEIGTPF-NJENFTAUSA-N

InChi Code: InChI=1S/C56H86N8O7/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-48(65)70-50(67)41-40-47(55(69)71-49(66)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2)61-54(68)44-36-38-46(39-37-44)64(3)43-45-42-59-53-51(60-45)52(57)62-56(58)63-53/h18-21,36-39,42,47H,4-17,22-35,40-41,43H2,1-3H3,(H,61,68)(H4,57,58,59,62,63)/b20-18+,21-19+/t47-/m1/s1

SMILES Code: CCCCCCCC/C=C/CCCCCCCC(OC(CC[C@H](C(OC(CCCCCCC/C=C/CCCCCCCC)=O)=O)NC(c1ccc(N(Cc2nc3c(N)nc(N)nc3nc2)C)cc1)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 983.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: de Smidt PC, van Berkel TJ. Prolonged serum half-life of antineoplastic drugs by incorporation into the low density lipoprotein. Cancer Res. 1990 Dec 1;50(23):7476-82. PubMed PMID: 2147578.