Geraniol | CAS#106-24-1 | monoterpenoid

Geraniol
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591619

CAS#: 106-24-1

Description: Geraniol is a monoterpenoid and an alcohol. It is the primary component of rose oil, palmarosa oil, and citronella oil. It is a colorless oil, although commercial samples can appear yellow.

Chemical Structure

Geraniol

CAS# 106-24-1

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 591619
Name: Geraniol
CAS#: 106-24-1
Chemical Formula: C10H18O
Exact Mass: 154.14
Molecular Weight: 154.250
Elemental Analysis: C, 77.87; H, 11.76; O, 10.37

Price and Availability

Size	Price	Availability	Quantity
25g	USD 220
100g	USD 360
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Geraniol; NSC 9279; NSC-9279; NSC9279

IUPAC/Chemical Name: 2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-

InChi Key: GLZPCOQZEFWAFX-JXMROGBWSA-N

InChi Code: InChI=1S/C10H18O/c1-9(2)5-4-6-10(3)7-8-11/h5,7,11H,4,6,8H2,1-3H3/b10-7+

SMILES Code: C/C(C)=C\CC/C(C)=C/CO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

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Biological target:	Geraniol, an olefinic terpene, was found to inhibit growth of Candida albicans and Saccharomyces cerevisiae strains.
In vitro activity:	This study then explored the effects of geraniol in PMACI-stimulated HMC-1 cells. Mast cell degranulation in the nasal mucosa released pro-inflammatory cytokines such as TNF-α, IL-1β, IL-8, and IL-6, chemokines such as MCP-1, and histamine, a major biogenic amine. In line with previous reports, we demonstrated that PMACI significantly enhanced HMC-1 cell expression of TNF-α, IL-1β, IL-6, and MCP-1 as well as histamine (Figure 2B–F). On the other hand, geraniol concentrations of 40, 80, and 160 μmol/L attenuated expression levels of TNF-α, IL-1β, and IL-6. Thirty percent, 21.6%, and 27.0% of IL-1β, IL-6, and TNF-α, respectively, were inhibited at geraniol concentrations of 160 μmol/L. Geraniol did not significantly alter MCP-1 expression. Geran-iol was also found to inhibit mRNA expression of TNF-α, IL-1β, IL-6, and MCP-1 (Figure 3A–D). Reference: Drug Des Devel Ther. 2018 Sep 11;12:2897-2903. https://pubmed.ncbi.nlm.nih.gov/30254419/
In vivo activity:	Compared with the control group, a single Dox injection (20 mg/kg) to rats resulted in a substantial rise of MDA along with significant reductions in GSH content and CAT activity (Figure 2A–C). It also significantly decreased the gene and protein expression of Nrf-2, Ho-1, GPx-1, and SOD-2 (Figure 3A–G). However, prophylactic supplementation with geraniol substantially recovered the modifications of these parameters in a dose-dependent manner. These findings reveal the potential antioxidant action of geraniol. Reference: Reference: Nutrients. 2022 Apr 13;14(8):1620. https://pubmed.ncbi.nlm.nih.gov/35458182/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	100.0	648.30
	Water	1.0	6.48

Preparing Stock Solutions

The following data is based on the product molecular weight 154.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Huang Y, Yang XL, Ni YH, Xu ZM. Geraniol suppresses proinflammatory mediators in phorbol 12-myristate 13-acetate with A23187-induced HMC-1 cells. Drug Des Devel Ther. 2018 Sep 11;12:2897-2903. doi: 10.2147/DDDT.S145702. PMID: 30254419; PMCID: PMC6141105. 2. Lee S, Park YR, Kim SH, Park EJ, Kang MJ, So I, Chun JN, Jeon JH. Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908. doi: 10.1002/cam4.864. Epub 2016 Sep 28. PMID: 27683099; PMCID: PMC5083744. 3. AlAsmari AF, Ali N, Alharbi M, Alqahtani F, Alasmari F, Almoqbel D, AlSwayyed M, Alshammari A, Alanazi MM, Alhoshani A, Al-Harbi NO. Geraniol Ameliorates Doxorubicin-Mediated Kidney Injury through Alteration of Antioxidant Status, Inflammation, and Apoptosis: Potential Roles of NF-κB and Nrf2/Ho-1. Nutrients. 2022 Apr 13;14(8):1620. doi: 10.3390/nu14081620. PMID: 35458182; PMCID: PMC9031157. 4. Atef MM, Emam MN, Abo El Gheit RE, Elbeltagi EM, Alshenawy HA, Radwan DA, Younis RL, Abd-Ellatif RN. Mechanistic Insights into Ameliorating Effect of Geraniol on D-Galactose Induced Memory Impairment in Rats. Neurochem Res. 2022 Jun;47(6):1664-1678. doi: 10.1007/s11064-022-03559-3. Epub 2022 Mar 2. PMID: 35235140; PMCID: PMC9124169.
In vitro protocol:	1. Huang Y, Yang XL, Ni YH, Xu ZM. Geraniol suppresses proinflammatory mediators in phorbol 12-myristate 13-acetate with A23187-induced HMC-1 cells. Drug Des Devel Ther. 2018 Sep 11;12:2897-2903. doi: 10.2147/DDDT.S145702. PMID: 30254419; PMCID: PMC6141105. 2. Lee S, Park YR, Kim SH, Park EJ, Kang MJ, So I, Chun JN, Jeon JH. Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908. doi: 10.1002/cam4.864. Epub 2016 Sep 28. PMID: 27683099; PMCID: PMC5083744.
In vivo protocol:	1. AlAsmari AF, Ali N, Alharbi M, Alqahtani F, Alasmari F, Almoqbel D, AlSwayyed M, Alshammari A, Alanazi MM, Alhoshani A, Al-Harbi NO. Geraniol Ameliorates Doxorubicin-Mediated Kidney Injury through Alteration of Antioxidant Status, Inflammation, and Apoptosis: Potential Roles of NF-κB and Nrf2/Ho-1. Nutrients. 2022 Apr 13;14(8):1620. doi: 10.3390/nu14081620. PMID: 35458182; PMCID: PMC9031157. 2. Atef MM, Emam MN, Abo El Gheit RE, Elbeltagi EM, Alshenawy HA, Radwan DA, Younis RL, Abd-Ellatif RN. Mechanistic Insights into Ameliorating Effect of Geraniol on D-Galactose Induced Memory Impairment in Rats. Neurochem Res. 2022 Jun;47(6):1664-1678. doi: 10.1007/s11064-022-03559-3. Epub 2022 Mar 2. PMID: 35235140; PMCID: PMC9124169.

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1. Huang Y, Yang XL, Ni YH, Xu ZM. Geraniol suppresses proinflammatory mediators in phorbol 12-myristate 13-acetate with A23187-induced HMC-1 cells. Drug Des Devel Ther. 2018 Sep 11;12:2897-2903. doi: 10.2147/DDDT.S145702. PMID: 30254419; PMCID: PMC6141105.
2. Lee S, Park YR, Kim SH, Park EJ, Kang MJ, So I, Chun JN, Jeon JH. Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908. doi: 10.1002/cam4.864. Epub 2016 Sep 28. PMID: 27683099; PMCID: PMC5083744.
3. AlAsmari AF, Ali N, Alharbi M, Alqahtani F, Alasmari F, Almoqbel D, AlSwayyed M, Alshammari A, Alanazi MM, Alhoshani A, Al-Harbi NO. Geraniol Ameliorates Doxorubicin-Mediated Kidney Injury through Alteration of Antioxidant Status, Inflammation, and Apoptosis: Potential Roles of NF-κB and Nrf2/Ho-1. Nutrients. 2022 Apr 13;14(8):1620. doi: 10.3390/nu14081620. PMID: 35458182; PMCID: PMC9031157.
4. Atef MM, Emam MN, Abo El Gheit RE, Elbeltagi EM, Alshenawy HA, Radwan DA, Younis RL, Abd-Ellatif RN. Mechanistic Insights into Ameliorating Effect of Geraniol on D-Galactose Induced Memory Impairment in Rats. Neurochem Res. 2022 Jun;47(6):1664-1678. doi: 10.1007/s11064-022-03559-3. Epub 2022 Mar 2. PMID: 35235140; PMCID: PMC9124169.

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