Bozepinib

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562971

CAS#: 1207993-83-6

Description: Bozepinib is an antitumor agent. It acts by inducing PKR-mediated apoptosis and synergizing with IFN.

Chemical Structure

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Bozepinib
CAS# 1207993-83-6
Instruction

Theoretical Analysis

MedKoo Cat#: 562971
Name: Bozepinib
CAS#: 1207993-83-6
Chemical Formula: C20H14Cl2N6O5S
Exact Mass: 520.01
Molecular Weight: 521.320
Elemental Analysis: C, 46.08; H, 2.71; Cl, 13.60; N, 16.12; O, 15.34; S, 6.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Bozepinib;

IUPAC/Chemical Name: 3-(2,6-dichloro-9H-purin-9-yl)-1-((4-nitrophenyl)sulfonyl)-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepine

InChi Key: ADWZQHLAYGEBHB-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H14Cl2N6O5S/c21-18-17-19(25-20(22)24-18)26(11-23-17)16-9-27(15-4-2-1-3-12(15)10-33-16)34(31,32)14-7-5-13(6-8-14)28(29)30/h1-8,11,16H,9-10H2

SMILES Code: O=S(N1CC(N2C=NC3=C2N=C(Cl)N=C3Cl)OCC4=CC=CC=C41)(C5=CC=C([N+]([O-])=O)C=C5)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 521.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cruz-López O, Ramírez A, Navarro SA, García MA, Marchal JA, Campos JM, Conejo-García A. 1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds. Future Med Chem. 2017 Jul;9(11):1129-1140. doi: 10.4155/fmc-2017-0006. Epub 2017 Jul 19. PubMed PMID: 28722472.

2: Ramírez A, Boulaiz H, Morata-Tarifa C, Perán M, Jiménez G, Picon-Ruiz M, Agil A, Cruz-López O, Conejo-García A, Campos JM, Sánchez A, García MA, Marchal JA. HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. Oncotarget. 2014 Jun 15;5(11):3590-606. PubMed PMID: 24946763; PubMed Central PMCID: PMC4116505.

3: Marchal JA, Carrasco E, Ramirez A, Jiménez G, Olmedo C, Peran M, Agil A, Conejo-García A, Cruz-López O, Campos JM, García MÁ. Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence. Drug Des Devel Ther. 2013 Oct 29;7:1301-13. doi: 10.2147/DDDT.S51354. eCollection 2013. PubMed PMID: 24194639; PubMed Central PMCID: PMC3815003.

4: López-Cara LC, Conejo-García A, Marchal JA, Macchione G, Cruz-López O, Boulaiz H, García MA, Rodríguez-Serrano F, Ramírez A, Cativiela C, Jiménez AI, García-Ruiz JM, Choquesillo-Lazarte D, Aránega A, Campos JM. New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazep in-3-yl]-9H-purine. Eur J Med Chem. 2011 Jan;46(1):249-58. doi: 10.1016/j.ejmech.2010.11.011. Epub 2010 Dec 3. PubMed PMID: 21126804.