L 681176

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596629

CAS#: 91386-17-3

Description: L 681176 is an inhibitor of angiotensin converting enzyme; isolated from Streptomyces sp.

Chemical Structure

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L 681176
CAS# 91386-17-3
Instruction

Theoretical Analysis

MedKoo Cat#: 596629
Name: L 681176
CAS#: 91386-17-3
Chemical Formula: C12H23N5O7
Exact Mass: 349.16
Molecular Weight: 349.340
Elemental Analysis: C, 41.26; H, 6.64; N, 20.05; O, 32.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 681176; L-681176; L681176; L-681,176; L 681,176; L681,176;

IUPAC/Chemical Name: (2-((1-carboxy-4-guanidino-3-hydroxybutyl)amino)ethyl)-L-aspartic acid

InChi Key: UULSZYUKAFTXQP-RRQHEKLDSA-N

InChi Code: InChI=1S/C12H23N5O7/c13-12(14)17-5-6(18)3-7(10(21)22)15-1-2-16-8(11(23)24)4-9(19)20/h6-8,15-16,18H,1-5H2,(H,19,20)(H,21,22)(H,23,24)(H4,13,14,17)/t6?,7?,8-/m0/s1

SMILES Code: O=C(O)C[C@@H](C(O)=O)NCCNC(C(O)=O)CC(O)CNC(N)=N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 349.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hensens OD, Liesch JM. Structure elucidation of angiotensin converting enzyme inhibitor L-681,176 from Streptomyces sp. MA 5143a. J Antibiot (Tokyo). 1984 May;37(5):466-8. PubMed PMID: 6203887.

2: Huang L, Rowin G, Dunn J, Sykes R, Dobna R, Mayles BA, Gross DM, Burg RW. Discovery, purification and characterization of the angiotensin converting enzyme inhibitor, L-681,176, produced by Streptomyces sp. MA 5143a. J Antibiot (Tokyo). 1984 May;37(5):462-5. PubMed PMID: 6203886.