L 643441

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 559098

CAS#: 78442-39-4

Description: L 643441 is a bioactive chemical.

Chemical Structure

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L 643441
CAS# 78442-39-4
Instruction

Theoretical Analysis

MedKoo Cat#: 559098
Name: L 643441
CAS#: 78442-39-4
Chemical Formula: C17H25N5O2S
Exact Mass: 363.17
Molecular Weight: 363.480
Elemental Analysis: C, 56.18; H, 6.93; N, 19.27; O, 8.80; S, 8.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 643441; L-643441; L643441; L-643,441; L 643,441; L643,441;

IUPAC/Chemical Name: 3-amino-4-((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)amino)-1,2,5-thiadiazole 1-oxide

InChi Key: DUPAVAVETJQPOR-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H25N5O2S/c18-16-17(21-25(23)20-16)19-8-5-11-24-15-7-4-6-14(12-15)13-22-9-2-1-3-10-22/h4,6-7,12H,1-3,5,8-11,13H2,(H2,18,20)(H,19,21)

SMILES Code: NC1=NS(N=C1NCCCOC2=CC=CC(CN3CCCCC3)=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 363.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang RW, Miwa GT, Argenbright LS, Lu AY. In vitro studies on the interaction of famotidine with liver microsomal cytochrome P-450. Biochem Pharmacol. 1988 Aug 1;37(15):3049-53. PubMed PMID: 2899433.

2: Reeves JJ, Stables R. The antisecretory profile of action of the H2-receptor antagonists, famotidine, loxtidine, ranitidine and L-643,441 on the rat isolated gastric mucosa. Agents Actions. 1987 Feb;20(1-2):22-8. PubMed PMID: 2883848.

3: Lin JH, Cocchetto DM, Yeh KC, Duggan DE. Comparative effects of H2-receptor antagonists on drug interaction in rats. Drug Metab Dispos. 1986 Nov-Dec;14(6):649-53. PubMed PMID: 2877821.

4: MacLeod KM, Wenkstern D, McNeill JH. Irreversible antagonism of histamine H2 receptors in guinea-pig myocardium. Eur J Pharmacol. 1986 May 27;124(3):331-6. PubMed PMID: 2874036.

5: Henry DA, Somerville KW, Kitchingman GK, Holmes IB, Tobert JA, Langman MJ. L-643.441: an H2-receptor antagonist with potent and long-lasting effects in man. Br J Clin Pharmacol. 1985 Aug;20(2):133-6. PubMed PMID: 2864050; PubMed Central PMCID: PMC1400675.

6: Pendleton RG, Cook PG, Shepherd-Rose A, Mangel AW. Effects of H2-receptor antagonists upon physiological acid secretory states in animals. J Pharmacol Exp Ther. 1985 Apr;233(1):64-9. PubMed PMID: 2858583.

7: Batzri S, Thompson WF, Toles R. Distortion of H2-antagonist equilibrium constants by uptake in rabbit gastric mucosal cells. Pharmacology. 1985;30(4):215-24. PubMed PMID: 2859616.

8: Shepherd-Rose AJ, Pendleton RG. Studies on the properties of 3-N-[3-[3-(1-piperidinomethyl)phenoxy]-propyl]amino-4-amino-1,2, 5-thiadiazole-1-oxide (L-643,441) as an H2-receptor antagonist in isolated gastric glands. Eur J Pharmacol. 1984 Oct 1;105(1-2):57-63. PubMed PMID: 6149144.

9: Batzri S, Harmon JW, Toles R. Comparison of cimetidine with new H2-antagonists in rabbit and guinea pig gastric cells. Eur J Pharmacol. 1983 Oct 14;94(1-2):1-8. PubMed PMID: 6140169.

10: Torchiana ML, Pendleton RG, Cook PG, Hanson CA, Clineschmidt BV. Apparent irreversible H2-receptor blocking and prolonged gastric antisecretory activities of 3-N-(3-[3-(1-piperidinomethyl)phenoxy]propyl) amino-4-amino-1,2,5-thiadiazole-1-oxide (L-643, 441). J Pharmacol Exp Ther. 1983 Mar;224(3):514-9. PubMed PMID: 6131118.