Tritoqualine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596553

CAS#: 14504-73-5

Description: Tritoqualine is a histamine H1 antagonist.

Chemical Structure

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Tritoqualine
CAS# 14504-73-5
Instruction

Theoretical Analysis

MedKoo Cat#: 596553
Name: Tritoqualine
CAS#: 14504-73-5
Chemical Formula: C26H32N2O8
Exact Mass: 500.22
Molecular Weight: 500.540
Elemental Analysis: C, 62.39; H, 6.44; N, 5.60; O, 25.57

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Tritoqualine; L-554; L 554; L554; Tritocualina; BRN 0634993;

IUPAC/Chemical Name: 7-amino-4,5,6-triethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one

InChi Key: IRGJVQIJENCTQF-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H32N2O8/c1-6-31-23-17-16(18(27)24(32-7-2)25(23)33-8-3)26(29)36-21(17)19-15-13(9-10-28(19)4)11-14-20(22(15)30-5)35-12-34-14/h11,19,21H,6-10,12,27H2,1-5H3

SMILES Code: O=C1OC(C2N(C)CCC3=CC4=C(OCO4)C(OC)=C23)C5=C1C(N)=C(OCC)C(OCC)=C5OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 500.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Köbberling J, Cüppers HJ, Hintze G, Richter K, Rommelmann F, Tillil H. [References for a blood glucose lowering effect of tritoqualine in insulin treated diabetic patients]. Med Klin (Munich). 1988 Sep 16;83(18):596-600. German. PubMed PMID: 3054462.

8: Wojtecka-Lukasik E, Maśliński S. Is histamine involved in ethanol-induced inflammation? Agents Actions. 1988 Apr;23(3-4):321-3. PubMed PMID: 2839966.

9: Franchi F, Codacci-Pisanelli G, Aronne T. Flu-like syndrome due to tritoqualine in cutaneous mastocytosis. Acta Haematol. 1988;79(4):228. PubMed PMID: 3132809.

10: Rehn D, Reimann HJ, von der Ohe M, Schmidt U, Hennings G. The influence of tritoqualin (Inhibostamin) on the plasma histamine level and its biorhythmic variations. Agents Actions. 1987 Dec;22(3-4):209-13. PubMed PMID: 3445817.

11: Nakagawa Y, Ogawa T, Umezu K, Sato S. Effect of tritoqualine on the proliferation of interleukin-3 dependent cell line and sensitive cells. Jpn J Pharmacol. 1987 Nov;45(3):417-24. PubMed PMID: 2893857.

12: Yuasa S, Nakao Y, Umezu K. Suppressive effect of tritoqualine on enzyme leakage induced by D-galactosamine in rat primary-cultured hepatocytes. Jpn J Pharmacol. 1987 Mar;43(3):263-6. PubMed PMID: 3586415.

13: Wojtecka-Lukasik E, Dzierzkowska J, Maśliński S. Inhibitory effect of tritoqualine on activation of latent polymorphonuclear leukocyte collagenase. Int J Tissue React. 1987;9(1):69-72. PubMed PMID: 2439471.

14: Umezu K, Yuasa S, Ichikawa A. Inhibitory mechanism of tritoqualine on histamine release from mast cells. Biochem Pharmacol. 1986 Sep 15;35(18):3137-42. PubMed PMID: 2428378.

15: Gastpar H, Sauer PH. [Rhinomanometric measurements following intranasal allergen provocation]. Dtsch Med Wochenschr. 1986 Jun 27;111(26):1022-4. German. PubMed PMID: 2873014.

16: Yuasa S, Sudoh A, Nakao Y, Umezu K. Suppressive effect of tritoqualine on lipid peroxidation and enzyme leakage induced by carbon tetrachloride in rat hepatocytes. Jpn J Pharmacol. 1986 Jun;41(2):205-10. PubMed PMID: 2875205.

17: Maśliński C, Fogel WA, Wyczółkowska J, Nowak JZ. Tritoqualine and some aspects of histamine metabolism. Arzneimittelforschung. 1986 May;36(5):822-5. PubMed PMID: 2425817.

18: Narimatsu A, Nakao K, Egawa M, Hara H, Kitada Y, Yamazaki S, Miyake M, Tanaka T, Katayama S, Hashimoto N, et al. [General pharmacological action of tritoqualine (TRQ; (+/-)-(R*)-7-amino-4, 5, 6-triethoxy-3-[(R*)-5, 6, 7, 8-tetrahydro-4-methoxy-6-methyl-1, 3-dioxolo [4, 5-g] isoquinolin-5-yl] phthalide]. Nihon Yakurigaku Zasshi. 1986 Apr;87(4):457-78. Japanese. PubMed PMID: 3721362.

19: Umezu K, Yuasa S, Sudoh A, Inagaki M. [Suppressive effect of tritoqualine (TRQ) on the acceleration of fibrosis in the liver]. Nihon Yakurigaku Zasshi. 1986 Mar;87(3):291-300. Japanese. PubMed PMID: 3710312.

20: Sudoh A, Yuasa S, Umezu K, Saitoh T. [Effect of tritoqualine (TRQ) on bile secretion in rats]. Nihon Yakurigaku Zasshi. 1986 Mar;87(3):265-71. Japanese. PubMed PMID: 3710311.