Dextramycine
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596429

CAS#: 134-90-7

Description: Dextramycine is an optic isomer of chloramphenicol which is not an antibiotic.

Chemical Structure

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Dextramycine
CAS# 134-90-7
Instruction

Theoretical Analysis

MedKoo Cat#: 596429
Name: Dextramycine
CAS#: 134-90-7
Chemical Formula: C11H12Cl2N2O5
Exact Mass: 322.01
Molecular Weight: 323.120
Elemental Analysis: C, 40.89; H, 3.74; Cl, 21.94; N, 8.67; O, 24.76

Price and Availability

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100mg USD 510 2 weeks
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Synonym: Dextramycine; Dextramycin; Dextromycetin; (+)-Chloramphenicol; L-threo-Chloramphenicol;

IUPAC/Chemical Name: 2,2-dichloro-N-((1S,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide

InChi Key: WIIZWVCIJKGZOK-IUCAKERBSA-N

InChi Code: InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m0/s1

SMILES Code: O=C(N[C@@H](CO)[C@@H](O)C1=CC=C([N+]([O-])=O)C=C1)C(Cl)Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 323.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shabad LM, Bogush TA, Konopleva IA, Belitsky GA. Dextramycine (the dextraisomer of chloramphenicol) as an inhibitor of the induction of lung adenomas in mice. Neoplasma. 1977;24:147-50. PMID: 865644.


2: Shabad LM, Belitsky GA, Bogush TA. Effect of chloramphenicol and dextramycine on the toxicity of carcinogenic hydrocarbons. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;82(1):13-23. doi: 10.1007/BF00304380. PMID: 4280213.


3: Yanovych D, Berendsen B, Zasadna Z, Rydchuk M, Czymai T. A study of the origin of chloramphenicol isomers in honey. Drug Test Anal. 2018 Mar;10(3):416-422. doi: 10.1002/dta.2234. Epub 2017 Jul 27. PMID: 28643431.


4: Bogush TA, Konopleva IA. [Protective effect of chloramphenicol and dextramycin following the adrenocorticolytic action of 7, 12-dimethylbenz(a)anthracene]. Biull Eksp Biol Med. 1977 Mar;83(3):296-8. Russian. PMID: 403980.