TC-A2317 HCl
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562762

CAS#: 1245907-03-2

Description: TC-A2317 HCl is an Aurora kinase A inhibitor.

Chemical Structure

img
TC-A2317 HCl
CAS# 1245907-03-2
Instruction

Theoretical Analysis

MedKoo Cat#: 562762
Name: TC-A2317 HCl
CAS#: 1245907-03-2
Chemical Formula: C19H29ClN6O
Exact Mass: 0.00
Molecular Weight: 392.930
Elemental Analysis: C, 58.08; H, 7.44; Cl, 9.02; N, 21.39; O, 4.07

Price and Availability

Size Price Availability Quantity
5mg USD 300 2 Weeks
25mg USD 850 2 Weeks
Bulk inquiry

Synonym: TC-A2317 HCl; TC-A2317 Hydrochloride; TCA2317 HCl; TC A2317 HCl; TC A2317 Hydrochloride; TCA2317 Hydrochloride; TC-A-2317 hydrochloride;

IUPAC/Chemical Name: 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride

InChi Key: DXVATYHPJJPMIN-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H28N6O.ClH/c1-12-9-16(22-17-10-14(3)24-25-17)23-18(15(12)11-20)21-13(2)7-6-8-19(4,5)26;/h9-10,13,26H,6-8H2,1-5H3,(H3,21,22,23,24,25);1H

SMILES Code: N#CC1=C(C)C=C(NC2=NNC(C)=C2)N=C1NC(C)CCCC(C)(O)C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 392.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Zumbar CT, Usubalieva A, King PD, Li X, Mifsud CS, Dalton HM, Sak M, Urio S, Bryant WM, McElroy JP, Farmer G, Lehman NL. The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells. J Neurooncol. 2018 May;137(3):481-492. doi: 10.1007/s11060-018-2755-2. Epub 2018 Feb 2. PubMed PMID: 29396807.

2: Min YH, Kim W, Kim JE. The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation. Oncotarget. 2016 Dec 20;7(51):84718-84735. doi: 10.18632/oncotarget.12448. PubMed PMID: 27713168; PubMed Central PMCID: PMC5356694.

3: Van Brocklyn JR, Wojton J, Meisen WH, Kellough DA, Ecsedy JA, Kaur B, Lehman NL. Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma. Cancer Res. 2014 Oct 1;74(19):5364-70. doi: 10.1158/0008-5472.CAN-14-0386. Epub 2014 Aug 8. PubMed PMID: 25106428; PubMed Central PMCID: PMC4528677.