Nummularine B

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MedKoo CAT#: 581220

CAS#: 53947-96-9

Description: Nummularine B is cyclopeptide alkaloids was isolated from the roots of Ziziphus jujuba. it has antiviral activity against the porcine epidemic diarrhea virus (PEDV) and potent inhibitory effects on PEDV replication.


Price and Availability

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Pricing updated 2020-08-11. Prices are subject to change without notice.

Nummularine B is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 581220
Name: Nummularine B
CAS#: 53947-96-9
Chemical Formula: C32H43N5O6
Exact Mass: 593.3213
Molecular Weight: 593.73
Elemental Analysis: C, 64.74; H, 7.30; N, 11.80; O, 16.17


Synonym: Nummularine B; Daechuine S27; N-Demethylamphibine H;

IUPAC/Chemical Name: Propanamide, 2-(methylamino)-N-(2-methyl-1-((3,3a,12,13,14,15,16,16a-octahydro-8-methoxy-13,16-dioxo-14-(phenylmethyl)-5,9-metheno-9H-pyrrolo(3,2-b)(1,5,8)oxadiazacyclopentadecin-1(2H)-yl)carbonyl)propyl)-

InChi Key: UCENISLVVUEBDB-FYWRMAATSA-N

InChi Code: InChI=1S/C32H43N5O6/c1-19(2)27(36-29(38)20(3)33-4)32(41)37-16-14-26-28(37)31(40)35-24(17-21-9-7-6-8-10-21)30(39)34-15-13-22-18-23(43-26)11-12-25(22)42-5/h6-13,15,19-20,22,24,26-28,33H,14,16-18H2,1-5H3,(H,34,39)(H,35,40)(H,36,38)/b15-13+

SMILES Code: CC(NC)C(NC(C(N1CCC(C1C(NC2CC3=CC=CC=C3)=O)OC(C4)=CC=C(OC)C4/C=C/NC2=O)=O)C(C)C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kang KB, Ming G, Kim GJ, Ha TK, Choi H, Oh WK, Sung SH. Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba. Phytochemistry. 2015 Nov;119:90-5. doi: 10.1016/j.phytochem.2015.09.001. Epub 2015 Sep 8. PubMed PMID: 26361730.

2: Panseeta P, Lomchoey K, Prabpai S, Kongsaeree P, Suksamrarn A, Ruchirawat S, Suksamrarn S. Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana. Phytochemistry. 2011 Jun;72(9):909-15. doi: 10.1016/j.phytochem.2011.03.003. Epub 2011 Mar 28. PubMed PMID: 21450320.

3: Tuenter E, Foubert K, Staerk D, Apers S, Pieters L. Isolation and structure elucidation of cyclopeptide alkaloids from Ziziphus nummularia and Ziziphus spina-christi by HPLC-DAD-MS and HPLC-PDA-(HRMS)-SPE-NMR. Phytochemistry. 2017 Jun;138:163-169. doi: 10.1016/j.phytochem.2017.02.029. Epub 2017 Mar 8. PubMed PMID: 28284565.