KHG26693

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562635

CAS#: 1497249-95-2

Description: KHG26693 is an anti-inflammatory and antioxidant agent. It acts by significantly decreasing blood glucose, triglycerides, cholesterol and increased insulin.

Chemical Structure

img
KHG26693
CAS# 1497249-95-2
Instruction

Theoretical Analysis

MedKoo Cat#: 562635
Name: KHG26693
CAS#: 1497249-95-2
Chemical Formula: C14H20N2S
Exact Mass: 248.13
Molecular Weight: 248.380
Elemental Analysis: C, 67.70; H, 8.12; N, 11.28; S, 12.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KHG26693; KHG 26693; KHG-26693;

IUPAC/Chemical Name: N-(adamantan-1-yl)-4-methylthiazol-2-amine

InChi Key: JMRLYCMPIVIOSE-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H20N2S/c1-9-8-17-13(15-9)16-14-5-10-2-11(6-14)4-12(3-10)7-14/h8,10-12H,2-7H2,1H3,(H,15,16)

SMILES Code: CC1=CSC(NC23CC4CC(C3)CC(C4)C2)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 248.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Yang SJ, Kim EA, Chang MJ, Kim J, Na JM, Choi SY, Cho SW. N-Adamantyl-4-Methylthiazol-2-Amine Attenuates Glutamate-Induced Oxidative Stress and Inflammation in the Brain. Neurotox Res. 2017 Jul;32(1):107-120. doi: 10.1007/s12640-017-9717-x. Epub 2017 Mar 11. PubMed PMID: 28285348.

2: Kim J, Cho CH, Hahn HG, Choi SY, Cho SW. Neuroprotective effects of N-adamantyl-4-methylthiazol-2-amine against amyloid β-induced oxidative stress in mouse hippocampus. Brain Res Bull. 2017 Jan;128:22-28. doi: 10.1016/j.brainresbull.2016.10.010. Epub 2016 Nov 2. PubMed PMID: 27816554.

3: Cho CH, Kim EA, Kim J, Choi SY, Yang SJ, Cho SW. N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons. Free Radic Res. 2016 Jun;50(6):678-90. doi: 10.3109/10715762.2016.1167277. Epub 2016 Apr 25. PubMed PMID: 27002191.

4: Cho CH, Kim J, Ahn JY, Hahn HG, Cho SW. N-adamantyl-4-methylthiazol-2-amine suppresses lipopolysaccharide-induced brain inflammation by regulating NF-κB signaling in mice. J Neuroimmunol. 2015 Dec 15;289:98-104. doi: 10.1016/j.jneuroim.2015.10.016. Epub 2015 Oct 26. PubMed PMID: 26616878.

5: Kim EA, Han AR, Choi J, Ahn JY, Choi SY, Cho SW. Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells. Int Immunopharmacol. 2014 Sep;22(1):73-83. doi: 10.1016/j.intimp.2014.06.022. Epub 2014 Jun 25. PubMed PMID: 24975832.

6: Yang SJ, Je Lee W, Kim EA, Dal Nam K, Hahn HG, Young Choi S, Cho SW. Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2014 Aug 5;736:26-34. doi: 10.1016/j.ejphar.2014.04.031. Epub 2014 May 4. PubMed PMID: 24797782.