WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581196
Description: Dactylocycline is novel tetracycline derivatives produced by a Dactylosporangium sp. the aglycone was cross resistant with tetracycline, the dactylocyclines proved active against certain tetracycline-resistant organisms.
MedKoo Cat#: 581196
Chemical Formula: C22H23ClN2O10
Exact Mass: 510.1041
Molecular Weight: 510.88
Elemental Analysis: C, 51.72; H, 4.54; Cl, 6.94; N, 5.48; O, 31.32
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Synonym: Dactylocyclinone; Sch 34164;
IUPAC/Chemical Name: 2-Naphthacenecarboxamide, 1,4,4a,5,5a,6,11,12a-octahydro-7-chloro-4-(dimethylamino)-1,11-dioxo-3,4a,6,10,12,12a-hexahydroxy-8-methoxy-, (4R-(4-alpha,4a-alpha,5a-alpha,6-beta,12-alpha))-
InChi Key: BCQXQSRYTBJTTG-XDXBOZIESA-N
InChi Code: InChI=1S/C22H23ClN2O10/c1-25(2)17-16(29)12(20(24)32)19(31)22(34)18(30)9-6(5-21(17,22)33)14(27)11-10(15(9)28)7(26)4-8(35-3)13(11)23/h4,6,14,17,26-27,29-30,33-34H,5H2,1-3H3,(H2,24,32)/t6-,14-,17+,21+,22?/m0/s1
SMILES Code: O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2(O)C[C@]3([H])[C@H](O)C4=C(C(C3=C(O)C21O)=O)C(O)=CC(OC)=C4Cl)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 510.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Devasthale PV, Mitscher LA, Telikepalli H, Vander Velde D, Zou JY, Ax HA, Tymiak AA. Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. III. Absolute stereochemistry of the dactylocyclines. J Antibiot (Tokyo). 1992 Dec;45(12):1907-13. PubMed PMID: 1490882.
2: Cacciapuoti A, Moss EL Jr, Menzel F Jr, Cramer CA, Weiss W, Loebenberg D, Hare RS, Miller GH. In vitro and in vivo characterization of novel 8-methoxy derivatives of chlortetracycline. J Antibiot (Tokyo). 1987 Oct;40(10):1426-30. PubMed PMID: 3680008.
3: Tymiak AA, Ax HA, Bolgar MS, Kahle AD, Porubcan MA, Andersen NH. Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. II. Structure elucidation. J Antibiot (Tokyo). 1992 Dec;45(12):1899-906. PubMed PMID: 1490881.
4: Patel M, Gullo VP, Hegde VR, Horan AC, Marquez JA, Vaughan R, Puar MS, Miller GH. A new tetracycline antibiotic from a Dactylosporangium species. Fermentation, isolation and structure elucidation. J Antibiot (Tokyo). 1987 Oct;40(10):1414-8. PubMed PMID: 3680006.