Sodium methanearsonate | CAS# 2163-80-6 | functions

Sodium methanearsonate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581177

CAS#: 2163-80-6

Description: Sodium methanearsonate is also known as Monosodium Acid Methane Arsonate Sesquihydrate. It is an environmental toxic compound. It also functions as a commonly used herbicide for weed control in grass.

Chemical Structure

Sodium methanearsonate

CAS# 2163-80-6

Instruction

Theoretical Analysis

MedKoo Cat#: 581177
Name: Sodium methanearsonate
CAS#: 2163-80-6
Chemical Formula: CH4AsNaO3
Exact Mass: 161.93
Molecular Weight: 161.950
Elemental Analysis: C, 7.42; H, 2.49; As, 46.26; Na, 14.20; O, 29.64

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 300
25mg	USD 600
100mg	USD 1500
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Sodium methanearsonate; Methylarsenic acid, sodium salt; Methylarsonat monosodny; Monosodium acid metharsonate;

IUPAC/Chemical Name: Arsonic acid, methyl-, monosodium salt

InChi Key: JITOKQVGRJSHHA-UHFFFAOYSA-M

InChi Code: InChI=1S/CH5AsO3.Na/c1-2(3,4)5;/h1H3,(H2,3,4,5);/q;+1/p-1

SMILES Code: C[As]([O-])(O)=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 161.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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2: Jaghabir MT, Abdelghani AA, Anderson AC. Histopathological effects of monosodium methanearsonate (MSMA) on New Zealand white rabbits (Oryctalagus cuniculus). Bull Environ Contam Toxicol. 1989 Feb;42(2):289-93. PubMed PMID: 2920237.

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4: Naqvi SM, Flagge CT, Hawkins RL. Arsenic uptake and depuration by red crayfish, Procambarus clarkii, exposed to various concentrations of monosodium methanearsonate (MSMA) herbicide. Bull Environ Contam Toxicol. 1990 Jul;45(1):94-100. PubMed PMID: 2383688.

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11: Morrissey CA, Albert CA, Dods PL, Cullen WR, Lai VW, Elliott JE. Arsenic accumulation in bark beetles and forest birds occupying mountain pine beetle infested stands treated with monosodium methanearsonate. Environ Sci Technol. 2007 Feb 15;41(4):1494-500. PubMed PMID: 17593762.

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13: Albert CA, Williams TD, Morrissey CA, Lai VW, Cullen WR, Elliott JE. Dose-dependent uptake, elimination, and toxicity of monosodium methanearsonate in adult zebra finches (Taeniopygia guttata). Environ Toxicol Chem. 2008 Mar;27(3):605-11. PubMed PMID: 17988177.

14: Eichstaedt CA, Antao T, Cardona A, Pagani L, Kivisild T, Mormina M. Positive selection of AS3MT to arsenic water in Andean populations. Mutat Res. 2015 Oct;780:97-102. doi: 10.1016/j.mrfmmm.2015.07.007. Epub 2015 Jul 29. PubMed PMID: 26366667; PubMed Central PMCID: PMC4896383.

15: Chen J, Bhattacharjee H, Rosen BP. ArsH is an organoarsenical oxidase that confers resistance to trivalent forms of the herbicide monosodium methylarsenate and the poultry growth promoter roxarsone. Mol Microbiol. 2015 Jun;96(5):1042-52. doi: 10.1111/mmi.12988. Epub 2015 Apr 6. PubMed PMID: 25732202; PubMed Central PMCID: PMC4447588.

16: Zeng X, Su S, Feng Q, Wang X, Zhang Y, Zhang L, Jiang S, Li A, Li L, Wang Y, Wu C, Bai L, Duan R. Arsenic speciation transformation and arsenite influx and efflux across the cell membrane of fungi investigated using HPLC-HG-AFS and in-situ XANES. Chemosphere. 2015 Jan;119:1163-1168. doi: 10.1016/j.chemosphere.2014.10.034. Epub 2014 Nov 1. PubMed PMID: 25460757.

17: Kuramata M, Sakakibara F, Kataoka R, Abe T, Asano M, Baba K, Takagi K, Ishikawa S. Arsenic biotransformation by Streptomyces sp. isolated from rice rhizosphere. Environ Microbiol. 2015 Jun;17(6):1897-909. doi: 10.1111/1462-2920.12572. Epub 2014 Aug 18. PubMed PMID: 25039305.

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