WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581173

CAS#: 518-61-6

Description: Dacemazine is used in treatment of Depression.

Chemical Structure

CAS# 518-61-6

Theoretical Analysis

MedKoo Cat#: 581173
Name: Dacemazine
CAS#: 518-61-6
Chemical Formula: C16H16N2OS
Exact Mass: 284.0983
Molecular Weight: 284.38
Elemental Analysis: C, 67.58; H, 5.67; N, 9.85; O, 5.63; S, 11.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Dacemazine; Ahistan; BRN 0027765; Dacemazinum; Dimethylglycylphenothiazine; Histantin richter;

IUPAC/Chemical Name: 10-((Dimethylamino)acetyl)-10H-phenothiazine


InChi Code: InChI=1S/C16H16N2OS/c1-17(2)11-16(19)18-12-7-3-5-9-14(12)20-15-10-6-4-8-13(15)18/h3-10H,11H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 284.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Payen L, Honorat M, Bouard C, Jacob G, Terreux R, Delalu H, Labarthe E, Guitton J. Quantification and kinetic study in plasma and tissues of (E)-1,1,4,4-tetramethyl-2-tetrazene, a liquid propellant and a transformation product of 1,1-dimethyl hydrazine. Anal Bioanal Chem. 2015 Sep;407(22):6721-9. doi: 10.1007/s00216-015-8829-5. Epub 2015 Jun 17. PubMed PMID: 26082396.

2: Navarro SD, Mauro MO, Pesarini JR, Ogo FM, Oliveira RJ. Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis. Genet Mol Res. 2015 Mar 6;14(1):1679-91. doi: 10.4238/2015.March.6.14. PubMed PMID: 25867310.

3: Štofilová J, Szabadosová V, Hrčková G, Salaj R, Bertková I, Hijová E, Strojný L, Bomba A. Co-administration of a probiotic strain Lactobacillus plantarum LS/07 CCM7766 with prebiotic inulin alleviates the intestinal inflammation in rats exposed to N,N-dimethylhydrazine. Int Immunopharmacol. 2015 Feb;24(2):361-368. doi: 10.1016/j.intimp.2014.12.022. Epub 2014 Dec 20. PubMed PMID: 25536541.

4: Bruskov VI, Yaguzhinsky LS, Masalimov ZK, Chernikov AV, Emelyanenko VI, Gudkov SV. [Continuous Generation of Hydrogen Peroxide in Water Containing Very Low Concentrations of Unsymmetrical Dimethylhydrazine]. Biofizika. 2015 Jul-Aug;60(4):673-80. Russian. PubMed PMID: 26394466.

5: Barbosa LC, Furtado RA, Bertanha HC, Tomazella IM, Costa ES, Bastos JK, Andrade e Silva ML, Tavares DC. Chemopreventive effects of (-)-hinokinin against 1,2-dimethylhydrazine-induced genotoxicity and preneoplastic lesions in rat colon. J Nat Prod. 2014 Oct 24;77(10):2312-5. doi: 10.1021/np500093u. Epub 2014 Oct 9. PubMed PMID: 25297647.

6: Hirao H, Chuanprasit P, Cheong YY, Wang X. How is a metabolic intermediate formed in the mechanism-based inactivation of cytochrome P450 by using 1,1-dimethylhydrazine: hydrogen abstraction or nitrogen oxidation? Chemistry. 2013 Jun 3;19(23):7361-9. doi: 10.1002/chem.201300689. Epub 2013 Apr 16. PubMed PMID: 23592585.

7: Kenessov B, Alimzhanova M, Sailaukhanuly Y, Baimatova N, Abilev M, Batyrbekova S, Carlsen L, Tulegenov A, Nauryzbayev M. Transformation products of 1,1-dimethylhydrazine and their distribution in soils of fall places of rocket carriers in Central Kazakhstan. Sci Total Environ. 2012 Jun 15;427-428:78-85. doi: 10.1016/j.scitotenv.2012.04.017. Epub 2012 May 1. PubMed PMID: 22554529.

8: Li W, Zhou M, Xu N, Hu Y, Wang C, Li D, Liu L, Li D. Comparative analysis of protective effects of curcumin, curcumin-β-cyclodextrin nanoparticle and nanoliposomal curcumin on unsymmetrical dimethyl hydrazine poisoning in mice. Bioengineered. 2016 Sep 2;7(5):334-341. Epub 2016 Aug 10. PubMed PMID: 27710431; PubMed Central PMCID: PMC5060975.

9: Lopes GA, Dias MC, Barbisan LF, Marchesan Rodrigues MA. Early Life and Postnatal Western Diet Feeding and Susceptibility to Chemically Induced Colonic Aberrant Crypt Foci in Male Rats Offspring. Nutr Cancer. 2016 Jul;68(5):811-7. doi: 10.1080/01635581.2016.1170167. Epub 2016 May 13. PubMed PMID: 27176572.

10: Kansal S, Negi AK, Bhatnagar A, Agnihotri N. Ras signaling pathway in the chemopreventive action of different ratios of fish oil and corn oil in experimentally induced colon carcinogenesis. Nutr Cancer. 2012;64(4):559-68. doi: 10.1080/01635581.2012.675619. Epub 2012 Apr 20. PubMed PMID: 22519408.

11: Poulsen M, Mortensen A, Binderup ML, Langkilde S, Markowski J, Dragsted LO. The effect of apple feeding on markers of colon carcinogenesis. Nutr Cancer. 2011;63(3):402-9. doi: 10.1080/01635581.2011.535961. PubMed PMID: 21432724.

12: 1,1-Dimethylhydrazine. IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 3:1425-36. Review. PubMed PMID: 10476423.


14: National Toxicology Program. 1,1-Dimethylhydrazine. Rep Carcinog. 2004;11:III107-8. PubMed PMID: 21105246.

15: Liboredo JC, Anastácio LR, Mattos LV, Nicoli JR, Correia MI. Impact of probiotic supplementation on mortality of induced 1,2-dimethylhydrazine carcinogenesis in a mouse model. Nutrition. 2010 Jul-Aug;26(7-8):779-83. doi: 10.1016/j.nut.2010.01.008. PubMed PMID: 20579593.

16: Carlsen L. The interplay between QSAR/QSPR studies and partial order ranking and formal concept analyses. Int J Mol Sci. 2009 Apr 17;10(4):1628-57. doi: 10.3390/ijms10041628. Review. PubMed PMID: 19468330; PubMed Central PMCID: PMC2680638.

17: Malysheva AG, Sotnikov EE, Moskovkin AS. [Asymmetrical dimethylhydrazine in the environment: problems of monitoring and ways of their solution]. Gig Sanit. 2003 Sep-Oct;(5):74-6. Russian. PubMed PMID: 14598764.

18: National Toxicology Program. 1,1-Dimethylhydrazine. Rep Carcinog. 2002;10:107-8. PubMed PMID: 15323050.

19: Xiang KM, Chen XD. [Effects of astragalosides on induction of colorectal aberrant crypt foci by dimethylhydrazine and metabolizing enzymes in liver microsomes in rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jul;30(7):1720-1, 1723. Chinese. PubMed PMID: 20650809.

20: Carlsen L, Kenesova OA, Batyrbekova SE. A preliminary assessment of the potential environmental and human health impact of unsymmetrical dimethylhydrazine as a result of space activities. Chemosphere. 2007 Apr;67(6):1108-16. Epub 2007 Jan 17. PubMed PMID: 17234248.