FICZ

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562437

CAS#: 172922-91-7

Description: FICZ is a potent aryl hydrogen receptor (AhR) agonist (Kd = 70 p M). It acts by inducing transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Chemical Structure

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FICZ
CAS# 172922-91-7
Instruction

Theoretical Analysis

MedKoo Cat#: 562437
Name: FICZ
CAS#: 172922-91-7
Chemical Formula: C19H10N2O
Exact Mass: 282.08
Molecular Weight: 282.300
Elemental Analysis: C, 80.84; H, 3.57; N, 9.92; O, 5.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: FICZ; 6-Formylindolo[3,2-b]carbazole;

IUPAC/Chemical Name: indolo[3,2-b]carbazole-6-carbaldehyde

InChi Key: OTWFDHQTFRXSAK-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H10N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10H

SMILES Code: O=CC(C1=NC2=CC=CC=C2C1=C3)=C4C3=NC5=CC=CC=C54

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 282.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bock KW. Human and rodent aryl hydrocarbon receptor (AHR): from mediator of dioxin toxicity to physiologic AHR functions and therapeutic options. Biol Chem. 2017 Apr 1;398(4):455-464. doi: 10.1515/hsz-2016-0303. Review. PubMed PMID: 27805907.

2: Bock KW. From dioxin toxicity to putative physiologic functions of the human Ah receptor in homeostasis of stem/progenitor cells. Biochem Pharmacol. 2017 Jan 1;123:1-7. doi: 10.1016/j.bcp.2016.06.015. Epub 2016 Jun 25. Review. PubMed PMID: 27349986.

3: Bock KW. Toward elucidation of dioxin-mediated chloracne and Ah receptor functions. Biochem Pharmacol. 2016 Jul 15;112:1-5. doi: 10.1016/j.bcp.2016.01.010. Epub 2016 Jan 23. Review. PubMed PMID: 26801687.

4: Ficz G. New insights into mechanisms that regulate DNA methylation patterning. J Exp Biol. 2015 Jan 1;218(Pt 1):14-20. doi: 10.1242/jeb.107961. Review. PubMed PMID: 25568447.

5: Ficz G, Gribben JG. Loss of 5-hydroxymethylcytosine in cancer: cause or consequence? Genomics. 2014 Nov;104(5):352-7. doi: 10.1016/j.ygeno.2014.08.017. Epub 2014 Aug 30. Review. PubMed PMID: 25179374; PubMed Central PMCID: PMC4566966.

6: Bock KW. Homeostatic control of xeno- and endobiotics in the drug-metabolizing enzyme system. Biochem Pharmacol. 2014 Jul 1;90(1):1-6. doi: 10.1016/j.bcp.2014.04.009. Epub 2014 May 16. Review. PubMed PMID: 24837423.

7: Sibilano R, Pucillo CE, Gri G. Allergic responses and aryl hydrocarbon receptor novel pathway of mast cell activation. Mol Immunol. 2015 Jan;63(1):69-73. doi: 10.1016/j.molimm.2014.02.015. Epub 2014 Mar 18. Review. PubMed PMID: 24656327.

8: Branco MR, Ficz G, Reik W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet. 2011 Nov 15;13(1):7-13. doi: 10.1038/nrg3080. Review. PubMed PMID: 22083101.

9: Ma Q. Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease. Expert Opin Drug Metab Toxicol. 2011 Oct;7(10):1267-93. doi: 10.1517/17425255.2011.614947. Epub 2011 Sep 2. Review. PubMed PMID: 21883026.

10: Heintzmann R, Ficz G. Breaking the resolution limit in light microscopy. Methods Cell Biol. 2007;81:561-80. Review. PubMed PMID: 17519184.

11: Heintzmann R, Ficz G. Breaking the resolution limit in light microscopy. Brief Funct Genomic Proteomic. 2006 Dec;5(4):289-301. Review. PubMed PMID: 17170013.