ASP-6537

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562213

CAS#: 524699-72-7

Description: ASP-6537, also known as FK881, is a selective and reversible cyclooxygenase-1 (COX-1) inhibitor.

Chemical Structure

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ASP-6537
CAS# 524699-72-7
Instruction

Theoretical Analysis

MedKoo Cat#: 562213
Name: ASP-6537
CAS#: 524699-72-7
Chemical Formula: C17H17N3O3
Exact Mass: 311.13
Molecular Weight: 311.341
Elemental Analysis: C, 65.58; H, 5.50; N, 13.50; O, 15.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ASP-6537; ASP 6537; ASP6537; FK-881; FR 122047; FK 881; FK881; FR-122047; FR122047;

IUPAC/Chemical Name: 3-Methoxy-1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole

InChi Key: OBAICMYWONZOSZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17N3O3/c1-21-14-8-4-12(5-9-14)16-18-17(23-3)19-20(16)13-6-10-15(22-2)11-7-13/h4-11H,1-3H3

SMILES Code: COC1=CC=C(C2=NC(OC)=NN2C3=CC=C(OC)C=C3)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 311.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sakata C, Suzuki KI, Morita Y, Kawasaki T. Additive antithrombotic effect of ASP6537, a selective cyclooxygenase (COX)-1 inhibitor, in combination with clopidogrel in guinea pigs. Eur J Pharmacol. 2017 Mar 5;798:72-76. doi: 10.1016/j.ejphar.2017.01.015. Epub 2017 Jan 14. PubMed PMID: 28095326.

2: Ofosu FA. Effective, selective and specific inhibition of COX-1 may overcome the "aspirin paradox". Thromb Res. 2013 Jul;132(1):1-2. doi: 10.1016/j.thromres.2013.04.011. Epub 2013 May 7. PubMed PMID: 23664562.

3: Sakata C, Kawasaki T, Kato Y, Abe M, Suzuki K, Ohmiya M, Funatsu T, Morita Y, Okada M. ASP6537, a novel highly selective cyclooxygenase-1 inhibitor, exerts potent antithrombotic effect without "aspirin dilemma". Thromb Res. 2013 Jul;132(1):56-62. doi: 10.1016/j.thromres.2013.03.005. Epub 2013 Mar 22. PubMed PMID: 23522855.

4: Imanishi J, Morita Y, Yoshimi E, Kuroda K, Masunaga T, Yamagami K, Kuno M, Hamachi E, Aoki S, Takahashi F, Nakamura K, Miyata S, Ohkubo Y, Mutoh S. Pharmacological profile of FK881(ASP6537), a novel potent and selective cyclooxygenase-1 inhibitor. Biochem Pharmacol. 2011 Oct 1;82(7):746-54. doi: 10.1016/j.bcp.2011.06.035. Epub 2011 Jul 2. PubMed PMID: 21745460.