JHN76359 | Slingshot inhibitor D3 | CAS#1715076-35-9

JHN76359
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527679

CAS#: 1715076-35-9

Description: JHN76359, also known as Slingshot inhibitor D3, is a novel Potent Inhibitor of the Protein Phosphatase Slingshot. This compound was first reported in ChemMedChem (2015), 10(12), 1980-1987 This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

JHN76359

CAS# 1715076-35-9

Instruction

Theoretical Analysis

MedKoo Cat#: 527679
Name: JHN76359
CAS#: 1715076-35-9
Chemical Formula: C25H19NO4S2
Exact Mass: 461.08
Molecular Weight: 461.550
Elemental Analysis: C, 65.06; H, 4.15; N, 3.03; O, 13.87; S, 13.89

Price and Availability

Size	Price	Availability
100mg	USD 1050	2 Weeks
200mg	USD 1650	2 Weeks
500mg	USD 2650	2 Weeks
1g	USD 3650	2 Weeks
2g	USD 5950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Slingshot inhibitor D3; JHN76359; JHN-76359; JHN 76359;

IUPAC/Chemical Name: (Z)-4-((4-((4-Oxo-2-thioxo-3-(o-tolyl)thiazolidin-5-ylidene)methyl)phenoxy)methyl)benzoic acid

InChi Key: JZFBPGPPIJBVMI-HMAPJEAMSA-N

InChi Code: InChI=1S/C25H19NO4S2/c1-16-4-2-3-5-21(16)26-23(27)22(32-25(26)31)14-17-8-12-20(13-9-17)30-15-18-6-10-19(11-7-18)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14-

SMILES Code: O=C(O)C1=CC=C(COC2=CC=C(/C=C(SC(N3C4=CC=CC=C4C)=S)/C3=O)C=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	Soluble in DMSO	0.0	0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 461.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Lee SY, Kim W, Lee YG, Kang HJ, Lee SH, Park SY, Min JK, Lee SR, Chung SJ. Identification of sennoside A as a novel inhibitor of the slingshot (SSH) family proteins related to cancer metastasis. Pharmacol Res. 2017 May;119:422-430. doi: 10.1016/j.phrs.2017.03.003. Epub 2017 Mar 6. PubMed PMID: 28274853.

2: Bao Z, Han X, Chen F, Jia X, Zhao J, Zhang C, Yong C, Tian S, Zhou X, Han L. Evidence for the involvement of cofilin in Aspergillus fumigatus internalization into type II alveolar epithelial cells. BMC Microbiol. 2015 Aug 13;15:161. doi: 10.1186/s12866-015-0500-y. PubMed PMID: 26268695; PubMed Central PMCID: PMC4542120.

3: Wang Y, Kuramitsu Y, Kitagawa T, Baron B, Yoshino S, Maehara S, Maehara Y, Oka M, Nakamura K. Cofilin-phosphatase slingshot-1L (SSH1L) is over-expressed in pancreatic cancer (PC) and contributes to tumor cell migration. Cancer Lett. 2015 May 1;360(2):171-6. doi: 10.1016/j.canlet.2015.02.015. Epub 2015 Feb 12. PubMed PMID: 25684665.

4: Homma Y, Kanno S, Sasaki K, Nishita M, Yasui A, Asano T, Ohashi K, Mizuno K. Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation. J Biol Chem. 2014 Sep 19;289(38):26302-13. doi: 10.1074/jbc.M114.565945. Epub 2014 Aug 6. PubMed PMID: 25100728; PubMed Central PMCID: PMC4176240.

5: Park H, Park SY, Ryu SE. Homology modeling and virtual screening approaches to identify potent inhibitors of slingshot phosphatase 1. J Mol Graph Model. 2013 Feb;39:65-70. doi: 10.1016/j.jmgm.2012.10.008. Epub 2012 Nov 8. PubMed PMID: 23220283.

6: Rana MK, Worthylake RA. Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility. J Biol Chem. 2012 Jun 22;287(26):21836-45. doi: 10.1074/jbc.M112.346114. Epub 2012 May 4. PubMed PMID: 22563075; PubMed Central PMCID: PMC3381146.

7: Oleinik NV, Krupenko NI, Krupenko SA. ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A. Oncogene. 2010 Nov 25;29(47):6233-44. doi: 10.1038/onc.2010.356. Epub 2010 Aug 23. PubMed PMID: 20729910; PubMed Central PMCID: PMC2992098.

8: Wang Z, Wang M, Carr BI. Involvement of receptor tyrosine phosphatase DEP-1 mediated PI3K-cofilin signaling pathway in sorafenib-induced cytoskeletal rearrangement in hepatoma cells. J Cell Physiol. 2010 Aug;224(2):559-65. doi: 10.1002/jcp.22160. PubMed PMID: 20432459.

9: Patterson KI, Brummer T, O'Brien PM, Daly RJ. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J. 2009 Mar 15;418(3):475-89. Review. PubMed PMID: 19228121.

10: Ishibashi F. High glucose increases phosphocofilin via phosphorylation of LIM kinase due to Rho/Rho kinase activation in cultured pig proximal tubular epithelial cells. Diabetes Res Clin Pract. 2008 Apr;80(1):24-33. Epub 2008 Feb 21. PubMed PMID: 18093681.

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