TDCIPP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527476

CAS#: 13674-87-8

Description: TDCIPP is a hepatotoxicity inducer, significantly up-regulating the expression of genes involved in endoplasmic reticulum stress and Toll-like receptor (TLR) pathway.

Chemical Structure

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TDCIPP
CAS# 13674-87-8
Instruction

Theoretical Analysis

MedKoo Cat#: 527476
Name: TDCIPP
CAS#: 13674-87-8
Chemical Formula: C9H15Cl6O4P
Exact Mass: 427.88
Molecular Weight: 430.889
Elemental Analysis: C, 25.09; H, 3.51; Cl, 49.36; O, 14.85; P, 7.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: TDCIPP

IUPAC/Chemical Name: Tris(1,3-dichloro-2-propyl) phosphate

InChi Key: ASLWPAWFJZFCKF-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H15Cl6O4P/c10-1-7(2-11)17-20(16,18-8(3-12)4-13)19-9(5-14)6-15/h7-9H,1-6H2

SMILES Code: O=P(OC(CCl)CCl)(OC(CCl)CCl)OC(CCl)CCl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 430.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hill KL, Hamers T, Kamstra JH, Willmore WG, Letcher RJ. Organophosphate triesters and selected metabolites enhance binding of thyroxine to human transthyretin in vitro. Toxicol Lett. 2018 Jan 3. pii: S0378-4274(17)31540-0. doi: 10.1016/j.toxlet.2017.12.030. [Epub ahead of print] PubMed PMID: 29306024.

2: Christia C, Poma G, Besis A, Samara C, Covaci A. Legacy and emerging organophosphοrus flame retardants in car dust from Greece: Implications for human exposure. Chemosphere. 2017 Dec 23;196:231-239. doi: 10.1016/j.chemosphere.2017.12.132. [Epub ahead of print] PubMed PMID: 29304461.

3: Kamishima M, Hattori T, Suzuki G, Matsukami H, Komine C, Horii Y, Watanabe G, Oti T, Sakamoto H, Soga T, Parhar IS, Kondo Y, Takigami H, Kawaguchi M. Early-life exposure to Tris(1,3-dichloroisopropyl) phosphate induces dose-dependent suppression of sexual behavior in male rats. J Appl Toxicol. 2017 Dec 22. doi: 10.1002/jat.3569. [Epub ahead of print] PubMed PMID: 29271492.

4: Dasgupta S, Vliet SM, Kupsco A, Leet JK, Altomare D, Volz DC. Tris(1,3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos. PeerJ. 2017 Dec 14;5:e4156. doi: 10.7717/peerj.4156. eCollection 2017. PubMed PMID: 29259843; PubMed Central PMCID: PMC5733366.

5: Shen B, Whitehead TP, Gill R, Dhaliwal J, Brown FR, Petreas M, Patton S, Hammond SK. Organophosphate flame retardants in dust collected from United States fire stations. Environ Int. 2017 Dec 13;112:41-48. doi: 10.1016/j.envint.2017.12.009. [Epub ahead of print] PubMed PMID: 29247842.

6: Carignan CC, Mínguez-Alarcón L, Williams PL, Meeker JD, Stapleton HM, Butt CM, Toth TL, Ford JB, Hauser R; EARTH Study Team. Paternal urinary concentrations of organophosphate flame retardant metabolites, fertility measures, and pregnancy outcomes among couples undergoing in vitro fertilization. Environ Int. 2017 Dec 11;111:232-238. doi: 10.1016/j.envint.2017.12.005. [Epub ahead of print] PubMed PMID: 29241080.

7: Briels N, Løseth ME, Ciesielski TM, Malarvannan G, Poma G, Kjærvik SA, Léon A, Cariou R, Covaci A, Jaspers VLB. In ovo transformation of two emerging flame retardants in Japanese quail (Coturnix japonica). Ecotoxicol Environ Saf. 2018 Mar;149:51-57. doi: 10.1016/j.ecoenv.2017.10.069. Epub 2017 Nov 15. PubMed PMID: 29149662.

8: Cristale J, Aragão Belé TG, Lacorte S, Rodrigues de Marchi MR. Occurrence and human exposure to brominated and organophosphorus flame retardants via indoor dust in a Brazilian city. Environ Pollut. 2017 Nov 9. pii: S0269-7491(17)32237-6. doi: 10.1016/j.envpol.2017.10.110. [Epub ahead of print] PubMed PMID: 29129432.

9: Li H, Yuan S, Su G, Li M, Wang Q, Zhu G, Letcher RJ, Li Y, Han Z, Liu C. Whole-Life-Stage Characterization in the Basic Biology of Daphnia magna and Effects of TDCIPP on Growth, Reproduction, Survival, and Transcription of Genes. Environ Sci Technol. 2017 Dec 5;51(23):13967-13975. doi: 10.1021/acs.est.7b04569. Epub 2017 Nov 17. PubMed PMID: 29115819.

10: Ren X, Zhao X, Duan X, Fang Z. Enhanced bio-concentration of tris(1,3-dichloro-2-propyl) phosphate in the presence of nano-TiO(2) can lead to adverse reproductive outcomes in zebrafish. Environ Pollut. 2017 Nov 3;233:612-622. doi: 10.1016/j.envpol.2017.10.101. [Epub ahead of print] PubMed PMID: 29107901.

11: Kupsco A, Dasgupta S, Nguyen C, Volz DC. Dynamic Alterations in DNA Methylation Precede Tris(1,3-dichloro-2-propyl)phosphate-Induced Delays in Zebrafish Epiboly. Environ Sci Technol Lett. 2017 Sep 12;4(9):367-373. doi: 10.1021/acs.estlett.7b00332. Epub 2017 Aug 11. PubMed PMID: 28993812; PubMed Central PMCID: PMC5630170.

12: Castorina R, Bradman A, Stapleton HM, Butt C, Avery D, Harley KG, Gunier RB, Holland N, Eskenazi B. Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort. Chemosphere. 2017 Dec;189:574-580. doi: 10.1016/j.chemosphere.2017.09.037. Epub 2017 Sep 12. PubMed PMID: 28963974.

13: Vojta Š, Melymuk L, Klánová J. Changes in Flame Retardant and Legacy Contaminant Concentrations in Indoor Air during Building Construction, Furnishing, and Use. Environ Sci Technol. 2017 Oct 17;51(20):11891-11899. doi: 10.1021/acs.est.7b03245. Epub 2017 Sep 27. PubMed PMID: 28910084.

14: Cheng R, Jia Y, Dai L, Liu C, Wang J, Li G, Yu L. Tris(1,3-dichloro-2-propyl) phosphate disrupts axonal growth, cholinergic system and motor behavior in early life zebrafish. Aquat Toxicol. 2017 Nov;192:7-15. doi: 10.1016/j.aquatox.2017.09.003. Epub 2017 Sep 5. PubMed PMID: 28898785.

15: Ginsberg GL, Belleggia G. Use of Monte Carlo analysis in a risk-based prioritization of toxic constituents in house dust. Environ Int. 2017 Dec;109:101-113. doi: 10.1016/j.envint.2017.06.009. Epub 2017 Sep 8. PubMed PMID: 28890219.

16: Li G, Ye H, Su G, Han Z, Xie C, Zhou B, Letcher RJ, Giesy JP, Yu H, Liu C. Establishment of a three-step method to evaluate effects of chemicals on development of zebrafish embryo/larvae. Chemosphere. 2017 Nov;186:209-217. doi: 10.1016/j.chemosphere.2017.07.163. Epub 2017 Aug 2. PubMed PMID: 28780448.

17: Sugeng EJ, Leonards PEG, van de Bor M. Brominated and organophosphorus flame retardants in body wipes and house dust, and an estimation of house dust hand-loadings in Dutch toddlers. Environ Res. 2017 Oct;158:789-797. doi: 10.1016/j.envres.2017.07.035. Epub 2017 Jul 27. PubMed PMID: 28756010.

18: Hammel SC, Hoffman K, Lorenzo AM, Chen A, Phillips AL, Butt CM, Sosa JA, Webster TF, Stapleton HM. Associations between flame retardant applications in furniture foam, house dust levels, and residents' serum levels. Environ Int. 2017 Oct;107:181-189. doi: 10.1016/j.envint.2017.07.015. Epub 2017 Jul 24. PubMed PMID: 28750223; PubMed Central PMCID: PMC5572835.

19: Jacobsen ML, Jaspers VLB, Ciesielski TM, Jenssen BM, Løseth ME, Briels N, Eulaers I, Leifsson PS, Rigét FF, Gomez-Ramirez P, Sonne C. Japanese quail (Coturnix japonica) liver and thyroid gland histopathology as a result of in ovo exposure to the flame retardants tris(1,3-dichloro-2-propyl) phosphate and Dechlorane Plus. J Toxicol Environ Health A. 2017;80(9):525-531. doi: 10.1080/15287394.2017.1336414. Epub 2017 Jul 11. PubMed PMID: 28696837.

20: He MJ, Yang T, Yang ZH, Li Q, Wei SQ. Occurrence and Distribution of Organophosphate Esters in Surface Soil and Street Dust from Chongqing, China: Implications for Human Exposure. Arch Environ Contam Toxicol. 2017 Oct;73(3):349-361. doi: 10.1007/s00244-017-0432-7. Epub 2017 Jul 8. PubMed PMID: 28689326.