GSK-A1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 427469

CAS#: 1416334-69-4

Description: GSK-A1 is a novel potent inhibitor of PI4KA.

Chemical Structure

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GSK-A1
CAS# 1416334-69-4
Instruction

Theoretical Analysis

MedKoo Cat#: 427469
Name: GSK-A1
CAS#: 1416334-69-4
Chemical Formula: C29H27FN6O4S
Exact Mass: 574.18
Molecular Weight: 574.631
Elemental Analysis: C, 60.62; H, 4.74; F, 3.31; N, 14.63; O, 11.14; S, 5.58

Price and Availability

Size Price Availability Quantity
5mg USD 285 2 Weeks
10mg USD 500 2 Weeks
25mg USD 900 2 Weeks
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Synonym: GSK-A1

IUPAC/Chemical Name: 5-[2-Amino-3-(4-morpholin-4-ylphenyl)benzimidazol-5-yl]-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide

InChi Key: AJOGHKUZDLYXKS-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H27FN6O4S/c1-39-28-27(41(37,38)34-24-5-3-2-4-23(24)30)17-20(18-32-28)19-6-11-25-26(16-19)36(29(31)33-25)22-9-7-21(8-10-22)35-12-14-40-15-13-35/h2-11,16-18,34H,12-15H2,1H3,(H2,31,33)

SMILES Code: O=S(C1=CC(C2=CC=C3C(N(C4=CC=C(N5CCOCC5)C=C4)C(N)=N3)=C2)=CN=C1OC)(NC6=CC=CC=C6F)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 574.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Beebe SJ, Reimann EM, Schlender KK. Purification and characterization of a cAMP- and Ca2+-calmodulin-independent glycogen synthase kinase from porcine renal cortex. J Biol Chem. 1984 Feb 10;259(3):1415-22. PubMed PMID: 6319398.