Chlorfenapyr
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571419

CAS#: 122453-73-0

Description: Chlorfenapyr is a pyrrole insecticide. It is nonneurotoxic.

Chemical Structure

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Chlorfenapyr
CAS# 122453-73-0
Instruction

Theoretical Analysis

MedKoo Cat#: 571419
Name: Chlorfenapyr
CAS#: 122453-73-0
Chemical Formula: C15H11BrClF3N2O
Exact Mass: 405.97
Molecular Weight: 407.620
Elemental Analysis: C, 44.20; H, 2.72; Br, 19.60; Cl, 8.70; F, 13.98; N, 6.87; O, 3.93

Price and Availability

Size Price Availability Quantity
100mg USD 350 2 Weeks
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Synonym: Chlorfenapyr; Pylon; AC303630; AC-303630; AC 303630;

IUPAC/Chemical Name: 1H-Pyrrole-3-carbonitrile, 4-bromo-2-(4-chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-

InChi Key: CWFOCCVIPCEQCK-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H11BrClF3N2O/c1-2-23-8-22-13(9-3-5-10(17)6-4-9)11(7-21)12(16)14(22)15(18,19)20/h3-6H,2,8H2,1H3

SMILES Code: N#CC1=C(C2=CC=C(Cl)C=C2)N(COCC)C(C(F)(F)F)=C1Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 407.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yuan JZ, Li QF, Huang JB, Gao JF. Effect of chlorfenapyr on cypermethrin-resistant Culex pipiens pallens Coq mosquitoes. Acta Trop. 2015 Mar;143:13-7. doi: 10.1016/j.actatropica.2014.12.002. Epub 2014 Dec 12. PubMed PMID: 25497774.

2: Oxborough RM, N'Guessan R, Jones R, Kitau J, Ngufor C, Malone D, Mosha FW, Rowland MW. The activity of the pyrrole insecticide chlorfenapyr in mosquito bioassay: towards a more rational testing and screening of non-neurotoxic insecticides for malaria vector control. Malar J. 2015 Mar 24;14:124. doi: 10.1186/s12936-015-0639-x. PubMed PMID: 25879231; PubMed Central PMCID: PMC4390098.

3: Huang JX, Liu CY, Lu DH, Chen JJ, Deng YC, Wang FH. Residue behavior and risk assessment of mixed formulation of imidacloprid and chlorfenapyr in chieh-qua under field conditions. Environ Monit Assess. 2015 Oct;187(10):650. doi: 10.1007/s10661-015-4846-2. Epub 2015 Sep 28. PubMed PMID: 26412080.

4: Verma V, Elamathi N, Velamuri PS, Sreehari U, Agrawal OP, Raghavendra K. Chlorfenapyr: irritant effect compared to other insecticides and its intrinsic toxicity in multiple-insecticide-susceptible and -resistant Anopheles stephensi (Diptera: Culicidae). J Vector Borne Dis. 2015 Mar;52(1):99-103. PubMed PMID: 25815874.

5: Ku JE, Joo YS, You JS, Chung SP, Lee HS. A case of survival after chlorfenapyr intoxication with acute pancreatitis. Clin Exp Emerg Med. 2015 Mar 31;2(1):63-66. eCollection 2015 Mar. PubMed PMID: 27752575; PubMed Central PMCID: PMC5052853.

6: Ngufor C, Critchley J, Fagbohoun J, N'Guessan R, Todjinou D, Rowland M. Chlorfenapyr (A Pyrrole Insecticide) Applied Alone or as a Mixture with Alpha-Cypermethrin for Indoor Residual Spraying against Pyrethroid Resistant Anopheles gambiae sl: An Experimental Hut Study in Cove, Benin. PLoS One. 2016 Sep 2;11(9):e0162210. doi: 10.1371/journal.pone.0162210. eCollection 2016. PubMed PMID: 27588945; PubMed Central PMCID: PMC5010291.

7: N'Guessan R, Ngufor C, Kudom AA, Boko P, Odjo A, Malone D, Rowland M. Mosquito nets treated with a mixture of chlorfenapyr and alphacypermethrin control pyrethroid resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes in West Africa. PLoS One. 2014 Feb 3;9(2):e87710. doi: 10.1371/journal.pone.0087710. eCollection 2014. PubMed PMID: 24498360; PubMed Central PMCID: PMC3912058.

8: Ullah S, Shah RM, Shad SA. Genetics, realized heritability and possible mechanism of chlorfenapyr resistance in Oxycarenus hyalinipennis (Lygaeidae: Hemiptera). Pestic Biochem Physiol. 2016 Oct;133:91-96. doi: 10.1016/j.pestbp.2016.02.007. Epub 2016 Feb 23. PubMed PMID: 27742367.

9: Lee J, Lee JH, Baek JM, Lee DS, Park IY, Won JM, Sung KY. Toxicity from intra-abdominal injection of chlorfenapyr. Case Rep Emerg Med. 2013;2013:425179. doi: 10.1155/2013/425179. Epub 2013 Apr 16. PubMed PMID: 23691373; PubMed Central PMCID: PMC3652055.

10: Al-Sarar AS, Abobakr Y, Bayoumi AE, Hussein HI. Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells. Environ Sci Pollut Res Int. 2015 Nov;22(21):17041-52. doi: 10.1007/s11356-015-4927-3. Epub 2015 Jul 1. PubMed PMID: 26122579.

11: Kang C, Kim DH, Kim SC, Kim DS. A patient fatality following the ingestion of a small amount of chlorfenapyr. J Emerg Trauma Shock. 2014 Jul;7(3):239-41. doi: 10.4103/0974-2700.136874. PubMed PMID: 25114438; PubMed Central PMCID: PMC4126128.

12: Tharaknath VR, Prabhakar YV, Kumar KS, Babu NK. Clinical and radiological findings in chlorfenapyr poisoning. Ann Indian Acad Neurol. 2013 Apr;16(2):252-4. doi: 10.4103/0972-2327.112486. PubMed PMID: 23956576; PubMed Central PMCID: PMC3724086.

13: N'Guessan R, Odjo A, Ngufor C, Malone D, Rowland M. A Chlorfenapyr Mixture Net Interceptor® G2 Shows High Efficacy and Wash Durability against Resistant Mosquitoes in West Africa. PLoS One. 2016 Nov 16;11(11):e0165925. doi: 10.1371/journal.pone.0165925. eCollection 2016. PubMed PMID: 27851828; PubMed Central PMCID: PMC5112870.

14: Baek BH, Kim SK, Yoon W, Heo TW, Lee YY, Kang HK. Chlorfenapyr-Induced Toxic Leukoencephalopathy with Radiologic Reversibility: A Case Report and Literature Review. Korean J Radiol. 2016 Mar-Apr;17(2):277-80. doi: 10.3348/kjr.2016.17.2.277. Epub 2016 Mar 2. Review. PubMed PMID: 26957914; PubMed Central PMCID: PMC4781768.

15: Athanassiou CG, Kavallieratos NG, Arthur FH, Throne JE. Residual efficacy of chlorfenapyr for control of stored-product psocids (Psocoptera). J Econ Entomol. 2014 Apr;107(2):854-9. PubMed PMID: 24772570.

16: Peterson CJ, Davis RW. Mobility, longevity and activity of chlorfenapyr in soils treated at a termiticidal rate. Pest Manag Sci. 2013 Jan;69(1):88-92. doi: 10.1002/ps.3366. Epub 2012 Nov 5. PubMed PMID: 23129480.

17: Oxborough RM, Kitau J, Matowo J, Feston E, Mndeme R, Mosha FW, Rowland MW. ITN mixtures of chlorfenapyr (Pyrrole) and alphacypermethrin (Pyrethroid) for control of pyrethroid resistant Anopheles arabiensis and Culex quinquefasciatus. PLoS One. 2013;8(2):e55781. doi: 10.1371/journal.pone.0055781. Epub 2013 Feb 7. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/9c1e150f-b310-45b9-b835-220e15489781. PubMed PMID: 23409042; PubMed Central PMCID: PMC3567122.

18: Abdel Ghani SB, Abdallah OI. Method validation and dissipation dynamics of chlorfenapyr in squash and okra. Food Chem. 2016 Mar 1;194:516-21. doi: 10.1016/j.foodchem.2015.08.053. Epub 2015 Aug 18. PubMed PMID: 26471587.

19: Raghavendra K, Barik TK, Bhatt RM, Srivastava HC, Sreehari U, Dash AP. Evaluation of the pyrrole insecticide chlorfenapyr for the control of Culex quinquefasciatus Say. Acta Trop. 2011 Apr;118(1):50-5. doi: 10.1016/j.actatropica.2011.02.001. Epub 2011 Feb 17. PubMed PMID: 21315680.

20: Ma Q, Liu Y, Zhang P, Li Y, Xiong L, Wang Q. Design, synthesis, and biological evaluation of various α-substituted benzylpyrroles based on the structures of insecticidal chlorfenapyr and natural pyrrolomycins. J Agric Food Chem. 2014 Jul 2;62(26):6072-81. doi: 10.1021/jf501377t. Epub 2014 Jun 19. PubMed PMID: 24914855. ^p