Tetramisole Hydrochloride
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MedKoo CAT#: 527043

CAS#: 5086-74-8

Description: Tetramisole Hydrochloride is an inhibitor of various mammalian alkaline phosphatases (i.e., liver, kidney, placenta, bone and tumor).

Chemical Structure

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Tetramisole Hydrochloride
CAS# 5086-74-8
Instruction

Theoretical Analysis

MedKoo Cat#: 527043
Name: Tetramisole Hydrochloride
CAS#: 5086-74-8
Chemical Formula: C11H13ClN2S
Exact Mass: 240.05
Molecular Weight: 240.749
Elemental Analysis: C, 54.88; H, 5.44; Cl, 14.72; N, 11.64; S, 13.32

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Tetramisole Hydrochloride

IUPAC/Chemical Name: 6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride

InChi Key: LAZPBGZRMVRFKY-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H

SMILES Code: [H]Cl.C12=NC(C3=CC=CC=C3)CN1CCS2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 240.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Belmessieri D, de la Houpliere A, Calder ED, Taylor JE, Smith AD. Stereodivergent organocatalytic intramolecular Michael addition/lactonization for the asymmetric synthesis of substituted dihydrobenzofurans and tetrahydrofurans. Chemistry. 2014 Jul 28;20(31):9762-9. doi: 10.1002/chem.201402684. Epub 2014 Jul 2. PubMed PMID: 24989672; PubMed Central PMCID: PMC4517160.

2: Gupta VK, Singh AK, Gupta B. Potentiometric sensor for the high throughput determination of tetramisole hydrochloride. Comb Chem High Throughput Screen. 2007 Aug;10(7):583-94. PubMed PMID: 17979641.

3: Amin AS, Dessouki HA. Facile colorimetric methods for the quantitative determination of tetramisole hydrochloride. Spectrochim Acta A Mol Biomol Spectrosc. 2002 Oct;58(12):2541-6. PubMed PMID: 12396035.

4: Robert JF, Hassanine A, Harraga S, Seilles E. [Imidazo(2,1-b)thiazole XII derivatives. Synthesis and research of immunoactivity in vitro on human T lymphocyte of 3-aroylmethyl and 2-aroyl-3-methyl(aryl)-5,6-dihydroimidaz o(2,1-b)thiazoles]. Ann Pharm Fr. 1995;53(6):261-71. French. PubMed PMID: 8572506.

5: Bergmann A. [Experimental Prototheca mastitis in cattle and therapy with tetramisole hydrochloride]. Berl Munch Tierarztl Wochenschr. 1993 Aug;106(8):257-60. German. PubMed PMID: 8216187.

6: Bergmann A. [Udder compatibility of tetramisole and levamisole hydrochloride and suggestion for the prescription of their intramammary use in cattle against Prototheca zopfii]. Berl Munch Tierarztl Wochenschr. 1993 Aug;106(8):253-6. German. PubMed PMID: 8216186.

7: Sane RT, Sapre DS, Nayak VG. An extractive spectrophotometric method for the determination of tetramisole hydrochloride in pharmaceutical preparations. Talanta. 1985 Feb;32(2):148-9. PubMed PMID: 18963812.

8: Oba MS, Mello Ede B, Dell'Porto A, Soares MA, Schumaker TT. [Critical test of the activity of tetramisole phosphate on gastrointestinal helminths of sheep]. Arq Inst Biol (Sao Paulo). 1979 Jul-Dec;46(3-4):127-30. Portuguese. PubMed PMID: 576034.

9: Granström G, Linde A. A comparison of ATP-degrading enzyme activities in rat incisor odontoblasts. J Histochem Cytochem. 1976 Sep;24(9):1026-32. PubMed PMID: 9454.

10: Renoux G, Renoux M. Stimulation of anti-Brucella vaccination in mice by tetramisole, a phenyl-imidothiazole salt. Infect Immun. 1973 Oct;8(4):544-8. PubMed PMID: 4200541; PubMed Central PMCID: PMC422889.

11: [Comparison of affects of bephenium hydroxynaphthoate, tetramisole hydrochloride and tetramisole pamoate in the treatment of Ancylostoma duodenale and Necator americanus infections]. Zhonghua Yi Xue Za Zhi. 1973;8:490-1. Chinese. PubMed PMID: 4200747.

12: Kim CH, Soh CT. [Anthelminthic Effectiveness Of 2,3,5,6-Tetrahydro 6-Phenyl-Imidazole (2,1-B) Thiazole Hydrochloride (=tetramisole) Upon Intestinal Parasites]. Kisaengchunghak Chapchi. 1970 Aug;8(2):48-50. Korean. PubMed PMID: 12913513.

13: Hart JA, James PS, Curr C. The anthelmintic efficiency of laevo-tetramisole hydrochloride against nematode parasites of sheep and cattle. Aust Vet J. 1969 Feb;45(2):73-7. PubMed PMID: 5813400.

14: Alicata JE, Furumoto HH. Efficacy and safety of l-tetramisole hydrochloride in experimental Cooperia punctata infection of dairy calves. Am J Vet Res. 1969 Jan;30(1):139-41. PubMed PMID: 5812435.

15: Walley JK. Tetramisole (dl 2,3,5,6-tetrahydro-6-phenyl-imidazo (2,1-b) thiazole hydrochloride--Nilverm) in the treatment of gastro-intestinal worms and lungworms in domestic animals. 1. Sheep and goats. Vet Rec. 1966 Mar 19;78(12):406-14. PubMed PMID: 5324698.