Ro 48-8587

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526598

CAS#: 211120-62-6

Description: Ro 48-8587 is a competitive AMPA receptor antagonist.

Chemical Structure

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Ro 48-8587
CAS# 211120-62-6
Instruction

Theoretical Analysis

MedKoo Cat#: 526598
Name: Ro 48-8587
CAS#: 211120-62-6
Chemical Formula: C12H7N7O4
Exact Mass: 313.06
Molecular Weight: 313.233
Elemental Analysis: C, 46.01; H, 2.25; N, 31.30; O, 20.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Ro 48-8587; Ro 488587; Ro 48 8587

IUPAC/Chemical Name: 9-Imidazol-1-yl-8-nitro-2,3,5,6-tetrahydro[1,2,4]-triazolo[1,5-c]quinazoline-2,5-dione

InChi Key: AVTCDZCFLPMWQN-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H7N7O4/c20-11-15-10-6-3-8(17-2-1-13-5-17)9(19(22)23)4-7(6)14-12(21)18(10)16-11/h1-5H,(H,14,21)(H,16,20)

SMILES Code: O=C1NN2C(NC3=C(C=C(N4C=CN=C4)C([N+]([O-])=O)=C3)C2=N1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 313.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Morin N, Morissette M, Grégoire L, Gomez-Mancilla B, Gasparini F, Di Paolo T. Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys. Neuropharmacology. 2013 Oct;73:216-31. doi: 10.1016/j.neuropharm.2013.05.028. Epub 2013 Jun 10. PubMed PMID: 23756168.

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5: Allison C, Pratt JA, Ripley TL, Stephens DN. alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionate receptor autoradiography in mouse brain after single and repeated withdrawal from diazepam. Eur J Neurosci. 2005 Feb;21(4):1045-56. PubMed PMID: 15787709.

6: Jouppila A, Pentikäinen OT, Settimo L, Nyrönen T, Haapalahti JP, Lampinen M, Mottershead DG, Johnson MS, Keinänen K. Determinants of antagonist binding at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D. Role of the conserved arginine 507 and glutamate 727 residues. Eur J Biochem. 2002 Dec;269(24):6261-70. PubMed PMID: 12473122.

7: Quirk JC, Linden AM, Strakhova M, Yu H, Skolnick P, Nisenbaum ES. A single residue contributes sensitivity to allosteric modulation of AMPA receptors by LY395153. Eur J Pharmacol. 2002 Nov 15;454(2-3):125-9. PubMed PMID: 12421639.

8: Lampinen M, Settimo L, Pentikainen OT, Jouppila A, Mottershead DG, Johnson MS, Keinanen K. Discrimination between agonists and antagonists by the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-selective glutamate receptor. A mutation analysis of the ligand-binding domain of GluR-D subunit. J Biol Chem. 2002 Nov 1;277(44):41940-7. Epub 2002 Aug 7. PubMed PMID: 12167621.

9: Mutel V, Ellis GJ, Adam G, Chaboz S, Nilly A, Messer J, Bleuel Z, Metzler V, Malherbe P, Schlaeger EJ, Roughley BS, Faull RL, Richards JG. Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. PubMed PMID: 11080213.

10: Mutel V, Trube G, Klingelschmidt A, Messer J, Bleuel Z, Humbel U, Clifford MM, Ellis GJ, Richards JG. Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain. J Neurochem. 1998 Jul;71(1):418-26. PubMed PMID: 9648892.