Thionazin

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571402

CAS#: 297-97-2

Description: Thionazin is an organophosphorous insecticide that functions by inhibiting cholinesterase.

Chemical Structure

Thionazin

CAS# 297-97-2

Instruction

Theoretical Analysis

MedKoo Cat#: 571402
Name: Thionazin
CAS#: 297-97-2
Chemical Formula: C8H13N2O3PS
Exact Mass: 248.04
Molecular Weight: 248.240
Elemental Analysis: C, 38.71; H, 5.28; N, 11.29; O, 19.34; P, 12.48; S, 12.92

Price and Availability

Size	Price	Availability	Quantity
50mg	USD 200
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Thionazin; Zynophos; AC 18133; AC-18133; AC18133

IUPAC/Chemical Name: O,O-Diethyl O-pyrazin-2-yl phosphorothioate

InChi Key: IRVDMKJLOCGUBJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H13N2O3PS/c1-3-11-14(15,12-4-2)13-8-7-9-5-6-10-8/h5-7H,3-4H2,1-2H3

SMILES Code: S=P(OCC)(OCC)OC1=NC=CN=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 248.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Salemi A, Rasoolzadeh R, Nejad MM, Vosough M. Ultrasonic assisted headspace single drop micro-extraction and gas chromatography with nitrogen-phosphorus detector for determination of organophosphorus pesticides in soil. Anal Chim Acta. 2013 Mar 26;769:121-6. doi: 10.1016/j.aca.2013.01.054. Epub 2013 Feb 8. PubMed PMID: 23498130.

2: Basheer C, Alnedhary AA, Rao BS, Lee HK. Determination of organophosphorous pesticides in wastewater samples using binary-solvent liquid-phase microextraction and solid-phase microextraction: a comparative study. Anal Chim Acta. 2007 Dec 19;605(2):147-52. Epub 2007 Oct 11. PubMed PMID: 18036377.

3: Kochman M, Gordin A, Alon T, Amirav A. Flow modulation comprehensive two-dimensional gas chromatography-mass spectrometry with a supersonic molecular beam. J Chromatogr A. 2006 Sep 29;1129(1):95-104. Epub 2006 Jul 10. PubMed PMID: 16834991.

4: Basheer C, Balaji G, Chua SH, Valiyaveettil S, Lee HK. Novel on-site sample preparation approach with a portable agitator using functional polymer-coated multi-fibers for the microextraction of organophosphorus pesticides in seawater. J Chromatogr A. 2011 Feb 4;1218(5):654-61. doi: 10.1016/j.chroma.2010.12.033. Epub 2010 Dec 16. PubMed PMID: 21208618.

5: Fiori G, Saglini V, Bertini F, Domenighetti G, Mombelli G. [Severe poisoning with the organophosphorus insecticide thionazine--2 cases with the development of adult respiratory distress syndrome (ARDS)]. Schweiz Med Wochenschr. 1987 Mar 14;117(11):399-401. French. PubMed PMID: 3576150.

6: Sepulcri F, Angehrn W, Wolf C. [Severe poisoning with a cholinesterase inhibitor]. Schweiz Med Wochenschr. 1987 Mar 28;117(13):487-90. German. PubMed PMID: 3576159.

7: Skrbić B. Organochlorine and organophosphate pesticide residues in wheat varieties from Serbia. Food Addit Contam. 2007 Jul;24(7):695-703. PubMed PMID: 17613054.

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