Tiamenidine
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561606

CAS#: 31428-61-2

Description: Tiamenidine is a centrally-acting alpha1 adrenergic receptor antagonist.

Chemical Structure

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Tiamenidine
CAS# 31428-61-2
Instruction

Theoretical Analysis

MedKoo Cat#: 561606
Name: Tiamenidine
CAS#: 31428-61-2
Chemical Formula: C8H10ClN3S
Exact Mass: 215.03
Molecular Weight: 215.690
Elemental Analysis: C, 44.55; H, 4.67; Cl, 16.43; N, 19.48; S, 14.86

Price and Availability

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10mg USD 500
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Synonym: Tiamenidine; Hoe-440;

IUPAC/Chemical Name: N-(2-Chloro-4-methylthiophen-3-yl)-4,5-dihydro-1H-imidazol-2-amine

InChi Key: CVWILQHZFWRYPB-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H10ClN3S/c1-5-4-13-7(9)6(5)12-8-10-2-3-11-8/h4H,2-3H2,1H3,(H2,10,11,12)

SMILES Code: CC1=CSC(Cl)=C1NC2=NCCN2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 215.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kobinger W. Rudolf Buchheim lecture. Drugs as tools in research on adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1986 Feb;332(2):113-23. Review. PubMed PMID: 3010138.

2: Struthers AD, Dollery CT. Central nervous system mechanisms in blood pressure control. Eur J Clin Pharmacol. 1985;28 Suppl:3-11. Review. PubMed PMID: 2865146.

3: Reid JL, Campbell BC, Hamilton CA. Withdrawal reactions following cessation of central alpha-adrenergic receptor agonists. Hypertension. 1984 Sep-Oct;6(5 Pt 2):II71-5. Review. PubMed PMID: 6150002.