Tinyatoxin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561553

CAS#: 58821-95-7

Description: Tinyatoxin is a neurotoxin that acts through the vanilloid receptors of sensory nerves.

Chemical Structure

img
Tinyatoxin
CAS# 58821-95-7
Instruction

Theoretical Analysis

MedKoo Cat#: 561553
Name: Tinyatoxin
CAS#: 58821-95-7
Chemical Formula: C35H28N4O5
Exact Mass: 584.21
Molecular Weight: 584.630
Elemental Analysis: C, 71.91; H, 4.83; N, 9.58; O, 13.68

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Tinyatoxin; TTX; TTN; TNX;

IUPAC/Chemical Name: (2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,3b,6,6a,9a,10,11,11a-octahydro-7H-2,9b-epoxyazuleno[5',4':3,4]benzo[1,2-d][1,3]dioxol-5-yl)methyl 2-(4-hydroxyphenyl)acetate

InChi Key: WWZMXEIBZCEIFB-UHFFFAOYSA-N

InChi Code: InChI=1S/C36H38O8/c1-21(2)34-17-23(4)36-28(32(34)42-35(43-34,44-36)19-25-8-6-5-7-9-25)15-26(18-33(40)29(36)14-22(3)31(33)39)20-41-30(38)16-24-10-12-27(37)13-11-24/h5-15,23,28-29,32,37,40H,1,16-20H2,2-4H3

SMILES Code: C=C(C)C(C1O2)(CC(C)C3(O4)C1C=C(COC(CC5=CC=C(O)C=C5)=O)CC6(O)C3C=C(C)C6=O)OC24CC7=CC=CC=C7

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 584.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: McDonald HA, Neelands TR, Kort M, Han P, Vos MH, Faltynek CR, Moreland RB, Puttfarcken PS. Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia. Eur J Pharmacol. 2008 Oct 31;596(1-3):62-9. doi: 10.1016/j.ejphar.2008.07.063. Epub 2008 Aug 5. PubMed PMID: 18755179.

2: Mannes AJ, Brown DC, Keller J, Cordes L, Eckenhoff RG, Caudle RM, Iadarola MJ, Meng QC. Measurement of resiniferatoxin in serum samples by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 5;823(2):184-8. PubMed PMID: 16039169.

3: Witte DG, Cassar SC, Masters JN, Esbenshade T, Hancock AA. Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. J Biomol Screen. 2002 Oct;7(5):466-75. PubMed PMID: 14599363.

4: Fraser MO, Chuang YC, Kim DY, Brady CM, Beckel JM, Yoshimura N, de Groat WC, Chancellor MB. Intravesical ultrapotent vanilloid receptor agonists: acute effects on animal models of bladder irritation. Urology. 2001 Jun;57(6 Suppl 1):111-2. PubMed PMID: 11378080.

5: Geiges D, Meyer T, Marte B, Vanek M, Weissgerber G, Stabel S, Pfeilschifter J, Fabbro D, Huwiler A. Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. Biochem Pharmacol. 1997 Mar 21;53(6):865-75. PubMed PMID: 9113106.

6: Acs G, Lee J, Marquez VE, Blumberg PM. Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes. Brain Res Mol Brain Res. 1996 Jan;35(1-2):173-82. PubMed PMID: 8717353.

7: Szallasi A, Lewin NA, Blumberg PM. Vanilloid (capsaicin) receptor in the rat: positive cooperativity of resiniferatoxin binding and its modulation by reduction and oxidation. J Pharmacol Exp Ther. 1993 Aug;266(2):678-83. PubMed PMID: 8355200.

8: Szallasi A, Szolcsanyi J, Szallasi Z, Blumberg PM. Inhibition of [3H]resiniferatoxin binding to rat dorsal root ganglion membranes as a novel approach in evaluating compounds with capsaicin-like activity. Naunyn Schmiedebergs Arch Pharmacol. 1991 Nov;344(5):551-6. PubMed PMID: 1811172.

9: Szallasi A, Blumberg PM. Characterization of vanilloid receptors in the dorsal horn of pig spinal cord. Brain Res. 1991 May 3;547(2):335-8. PubMed PMID: 1884211.

10: Williamson EM, Westwick J, Evans FJ. The effect of daphnane esters on platelet aggregation and erythema of the mouse ear. J Pharm Pharmacol. 1980 May;32(5):373-4. PubMed PMID: 6104710.