CIDD-0067106

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MedKoo CAT#: 407849

CAS#: Unknown

Description: CIDD-0067106. has potent and selective antiproliferative activities. Mechanisms of action studies show they inhibit the activity of the mTORC1 pathway. CIDD-0067106 also showed Selective Activity against Androgen Receptor-Positive Breast Cancer Cells.

Chemical Structure

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CIDD-0067106
CAS# Unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 407849
Name: CIDD-0067106
CAS#: Unknown
Chemical Formula: C26H29N3O4
Exact Mass: 447.22
Molecular Weight: 447.535
Elemental Analysis: C, 69.78; H, 6.53; N, 9.39; O, 14.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CIDD-0067106; CIDD 0067106; CIDD0067106.

IUPAC/Chemical Name: methyl ((6-(5-(4-((3-methylbut-2-en-1-yl)oxy)phenyl)oxazol-2-yl)pyridin-3-yl)methyl)-L-prolinate

InChi Key: KWCAEMFGVDPGNT-QHCPKHFHSA-N

InChi Code: InChI=1S/C26H29N3O4/c1-18(2)12-14-32-21-9-7-20(8-10-21)24-16-28-25(33-24)22-11-6-19(15-27-22)17-29-13-4-5-23(29)26(30)31-3/h6-12,15-16,23H,4-5,13-14,17H2,1-3H3/t23-/m0/s1

SMILES Code: C/C(C)=C\COC1=CC=C(C2=CN=C(C3=NC=C(CN4CCC[C@H]4C(OC)=O)C=C3)O2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Targeted therapies for ER+/PR+ and HER2-amplified breast cancers have improved patient survival, but there are no therapies for triple negative breast cancers (TNBC) that lack expression of estrogen and progesterone receptors (ER/PR), or amplification or overexpression of HER2. Gene expression profiling of TNBC has identified molecular subtypes and representative cell lines. An extract of the Texas

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 447.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Robles AJ, McCowen S, Cai S, Glassman M, Ruiz F 2nd, Cichewicz RH, McHardy SF,
Mooberry SL. Structure-Activity Relationships of New Natural Product-Based
Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast
Cancer Cells. J Med Chem. 2017 Nov 3. doi: 10.1021/acs.jmedchem.7b01228. [Epub
ahead of print] PubMed PMID: 29053266.