CaMKII-IN-1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581018

CAS#: 1208123-85-6

Description: CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.

Chemical Structure

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CaMKII-IN-1
CAS# 1208123-85-6
Instruction

Theoretical Analysis

MedKoo Cat#: 581018
Name: CaMKII-IN-1
CAS#: 1208123-85-6
Chemical Formula: C29H30ClN5O2S
Exact Mass: 547.18
Molecular Weight: 548.100
Elemental Analysis: C, 63.55; H, 5.52; Cl, 6.47; N, 12.78; O, 5.84; S, 5.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CaMKII-IN-1; CaMKII; CaMKII IN-1; CaMKII IN 1; CaMKII-IN 1.

IUPAC/Chemical Name: N-[6-Benzyl-2-(2-phenylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]-3-chloro-2-methylbenzenesulfonamide

InChi Key: LGUUETDTMQTHML-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H30ClN5O2S/c1-21-25(30)13-8-14-27(21)38(36,37)34-28-24-20-35(19-23-11-6-3-7-12-23)18-16-26(24)32-29(33-28)31-17-15-22-9-4-2-5-10-22/h2-14H,15-20H2,1H3,(H2,31,32,33,34)

SMILES Code: O=S(C1=CC=CC(Cl)=C1C)(NC2=C(CN(CC3=CC=CC=C3)CC4)C4=NC(NCCC5=CC=CC=C5)=N2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 548.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in
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2: Chen W, An P, Quan XJ, Zhang J, Zhou ZY, Zou LP, Luo HS.
Ca(2+)/calmodulin-dependent protein kinase II regulates colon cancer
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3: Joseph JS, Ayeleso AO, Mukwevho E. Role of exercise-induced calmodulin protein
kinase (CAMK)II activation in the regulation of omega-6 fatty acids and lipid
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4: Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q, Hu G.
Differential effects on lung and bone metastasis of breast cancer by Wnt
signalling inhibitor DKK1. Nat Cell Biol. 2017 Oct;19(10):1274-1285. doi:
10.1038/ncb3613. Epub 2017 Sep 11. PubMed PMID: 28892080.


5: Burgos JI, Yeves AM, Barrena JP, Portiansky EL, Vila-Petroff MG, Ennis IL.
Nitric oxide and CaMKII: Critical steps in the cardiac contractile response To
IGF-1 and swim training. J Mol Cell Cardiol. 2017 Sep 1;112:16-26. doi:
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6: Tsai CY, Kuo WW, Shibu MA, Lin YM, Liu CN, Chen YH, Day CH, Shen CY,
Viswanadha VP, Huang CY. E2/ER β inhibit ISO-induced cardiac cellular hypertrophy
by suppressing Ca2+-calcineurin signaling. PLoS One. 2017 Sep 1;12(9):e0184153.
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7: Li J, Tang B, Zhang W, Wang C, Yang S, Zhang B, Gao X. Relationship and
mechanism of Kv2.1 expression to ADH secretion in rats with heart failure. Am J
Transl Res. 2017 Aug 15;9(8):3687-3695. eCollection 2017. PubMed PMID: 28861159;
PubMed Central PMCID: PMC5575182.


8: Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela
A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M,
Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D. Impaired calcium
homeostasis is associated with sudden cardiac death and arrhythmias in a genetic
equivalent mouse model of the human HRC-Ser96Ala variant. Cardiovasc Res. 2017
Sep 1;113(11):1403-1417. doi: 10.1093/cvr/cvx113. PubMed PMID: 28859293.


9: Ge L, Wang Z, Li C, Zhang Y, Chen L. Suppression of oxidative stress and
apoptosis in electrically stimulated neonatal rat cardiomyocytes by resveratrol
and underlying mechanisms. J Cardiovasc Pharmacol. 2017 Aug 18. doi:
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10: Wang R, Yin YX, Mahmood Q, Wang XJ, Gao YP, Gou GJ, Ahmed MM, Kohji F, Du YZ,
Han F. Calmodulin inhibitor ameliorates cognitive dysfunction via inhibiting
nitrosative stress and NLRP3 signaling in mice with bilateral carotid artery
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Epub 2017 Aug 28. PubMed PMID: 28851042.


11: Chen Y, Yuan J, Jiang G, Zhu J, Zou Y, Lv Q. Lercanidipine attenuates
angiotensin II-induced cardiomyocyte hypertrophy by blocking calcineurin-NFAT3
and CaMKII-HDAC4 signaling. Mol Med Rep. 2017 Oct;16(4):4545-4552. doi:
10.3892/mmr.2017.7211. Epub 2017 Aug 10. PubMed PMID: 28849081.


12: Espejo MS, Aiello I, Sepúlveda M, Vila Petroff MG, Aiello EA, De Giusti VC.
The reduced myofilament responsiveness to calcium contributes to the negative
force-frequency relationship in rat cardiomyocytes: role of reactive oxygen
species and p-38 map kinase. Pflugers Arch. 2017 Aug 23. doi:
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13: Andrei SR, Ghosh M, Sinharoy P, Dey S, Bratz IN, Damron DS. TRPA1 ion channel
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15: Jiang S, Huo D, Wang X, Zhao H, Tan J, Zeng Q, OʼRourke ST, Sun C.
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17: Liao Q, Zhang R, Wang X, Nian W, Ke L, Ouyang W, Zhang Z. Effect of fluoride
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C, Wu X, Wu J, Wu K, Gan X, Li G, Li L, Forman SJ, Chan WC, Xu R, Huang W.
Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma. Cancer
Cell. 2017 Jul 10;32(1):115-128.e7. doi: 10.1016/j.ccell.2017.06.001. PubMed
PMID: 28697340; PubMed Central PMCID: PMC5552197.


19: Wang H, Do DC, Liu J, Wang B, Qu J, Ke X, Luo X, Tang HM, Tang HL, Hu C,
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20: Zhong P, Quan D, Huang Y, Huang H. CaMKII Activation Promotes Cardiac
Electrical Remodeling and Increases the Susceptibility to Arrhythmia Induction in
High-fat Diet-Fed Mice With Hyperlipidemia Conditions. J Cardiovasc Pharmacol.
2017 Oct;70(4):245-254. doi: 10.1097/FJC.0000000000000512. PubMed PMID: 28662005.