KUNG94

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530910

CAS#: 2134571-29-0

Description: KUNG94 is a potent and selective Grp94 inhibitor (IC50 = 8 nM). KUNG94 manifests Grp94-selective inhibition in cells and represents a new scaffold for the development of Grp94-selective inhibitors.Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the 90 kDa heat shock protein (Hsp90) family and represents a promising therapeutic target for the treatment of several diseases.

Chemical Structure

img
KUNG94
CAS# 2134571-29-0
Instruction

Theoretical Analysis

MedKoo Cat#: 530910
Name: KUNG94
CAS#: 2134571-29-0
Chemical Formula: C22H18FNO3
Exact Mass: 363.13
Molecular Weight: 363.388
Elemental Analysis: C, 72.72; H, 4.99; F, 5.23; N, 3.85; O, 13.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KUNG94; KUNG-94; KUNG 94.

IUPAC/Chemical Name: (5-(4-fluorobenzyl)-2,4-dihydroxyphenyl)(isoindolin-2-yl)methanone

InChi Key: SDHXQALTNKXTMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H18FNO3/c23-18-7-5-14(6-8-18)9-17-10-19(21(26)11-20(17)25)22(27)24-12-15-3-1-2-4-16(15)13-24/h1-8,10-11,25-26H,9,12-13H2

SMILES Code: FC1=CC=C(CC2=C(O)C=C(O)C(C(N3CC(C=CC=C4)=C4C3)=O)=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 363.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Resorcinol-Based Grp94-Selective Inhibitors
Anuj Khandelwal,†,∥,§ Vincent M. Crowley,†,§ and Brian S. J. Blagg*,‡
†Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott Hall 4070, Lawrence, Kansas
66045, United States
‡Warren Family Research Center for Drug Discovery and Development and Department of Chemistry & Biochemistry, University of
Notre Dame, 305 McCourtney Hall, Notre Dame, Indiana 46556, United States