BIBX 1382 Dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561225

CAS#: 1216920-18-1

Description: BIBX 1382 dihydrochloride blocks Lassa, Ebola and Marburg viruses. BIBX 1382 dihydrochloride blocked both Lassa and Ebola virus glycoprotein-dependent cell entry. This compound may be used as a tool to understand conserved virus-host interactions, and implicate host cell kinases that may be targets for broad spectrum therapeutic intervention.

Chemical Structure

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BIBX 1382 Dihydrochloride
CAS# 1216920-18-1
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 561225
Name: BIBX 1382 Dihydrochloride
CAS#: 1216920-18-1
Chemical Formula: C18H21Cl3FN7
Exact Mass: 0.00
Molecular Weight: 460.760
Elemental Analysis: C, 46.92; H, 4.59; Cl, 23.08; F, 4.12; N, 21.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BIBX 1382 Dihydrochloride; BIBX-1382 Dihydrochloride; BIBX1382 Dihydrochloride; Falnidamol dihydrochloride; Falnidamol 2HCl; BIBX 1382 2HCl; BIBX-1382 2HCl; BIBX1382 2HCl

IUPAC/Chemical Name: N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride

InChi Key: RFXGEKWBTCMDAW-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H19ClFN7.2ClH/c1-27-6-4-11(5-7-27)25-18-21-9-15-16(26-18)17(23-10-22-15)24-12-2-3-14(20)13(19)8-12;;/h2-3,8-11H,4-7H2,1H3,(H,21,25,26)(H,22,23,24);2*1H

SMILES Code: CN1CCC(NC2=NC=C(N=CN=C3NC4=CC=C(F)C(Cl)=C4)C3=N2)CC1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Highly selective EGFR-kinase inhibitor.
In vitro activity: EGFR stimulation also increased T47D cell proliferation. Blocking EGFR activation with BIBX1382 or gefitinib completely abolished both FDG uptake and proliferation effects. Reference: PLoS One. 2019 Sep 18;14(9):e0221294. https://pubmed.ncbi.nlm.nih.gov/31532771/
In vivo activity: The male and female LDLR deficient mice under Western diet containing 21% fat and 0.2% cholesterol content were cotreated with control and HB-EGF ASOs for 12 weeks. An EGFR blocker BIBX1382 administration suppressed the hepatic TG secretion rate, suggesting a positive role of the HB-EGF signaling for the hepatic VLDL production. Reference: Nutr Metab Cardiovasc Dis. 2019 Mar;29(3):306-315. https://pubmed.ncbi.nlm.nih.gov/30738642/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.4 42.08
Water 19.4 42.08

Preparing Stock Solutions

The following data is based on the product molecular weight 460.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Jung KH, Lee EJ, Park JW, Lee JH, Moon SH, Cho YS, Lee KH. EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling. PLoS One. 2019 Sep 18;14(9):e0221294. doi: 10.1371/journal.pone.0221294. PMID: 31532771; PMCID: PMC6750601. 2. Kim S, Graham MJ, Lee RG, Yang L, Kim S, Subramanian V, Layne JD, Cai L, Temel RE, Shih D, Lusis AJ, Berliner JA, Lee S. Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis. Nutr Metab Cardiovasc Dis. 2019 Mar;29(3):306-315. doi: 10.1016/j.numecd.2018.12.006. Epub 2019 Jan 9. PMID: 30738642; PMCID: PMC6452438.
In vitro protocol: 1. Jung KH, Lee EJ, Park JW, Lee JH, Moon SH, Cho YS, Lee KH. EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling. PLoS One. 2019 Sep 18;14(9):e0221294. doi: 10.1371/journal.pone.0221294. PMID: 31532771; PMCID: PMC6750601.
In vivo protocol: 1. Kim S, Graham MJ, Lee RG, Yang L, Kim S, Subramanian V, Layne JD, Cai L, Temel RE, Shih D, Lusis AJ, Berliner JA, Lee S. Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis. Nutr Metab Cardiovasc Dis. 2019 Mar;29(3):306-315. doi: 10.1016/j.numecd.2018.12.006. Epub 2019 Jan 9. PMID: 30738642; PMCID: PMC6452438.

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1: Mohr EL, McMullan LK, Lo MK, Spengler JR, Bergeron É, Albariño CG, Shrivastava-Ranjan P, Chiang CF, Nichol ST, Spiropoulou CF, Flint M. Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses. Antiviral Res. 2015 Aug;120:40-7. doi: 10.1016/j.antiviral.2015.05.003. Epub 2015 May 16. PubMed PMID: 25986249.