OUP-186

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558257

CAS#: 1480830-24-7

Description: OUP-186 is a high affinity and human/rat species-selective histamine H3 receptor antagonist. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 μM (R)-(-)-α-methylhistamine (H3R agonist). OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells.

Chemical Structure

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OUP-186
CAS# 1480830-24-7
Instruction

Theoretical Analysis

MedKoo Cat#: 558257
Name: OUP-186
CAS#: 1480830-24-7
Chemical Formula: C19H30ClN3S
Exact Mass: 367.18
Molecular Weight: 367.980
Elemental Analysis: C, 62.02; H, 8.22; Cl, 9.63; N, 11.42; S, 8.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: OUP-186; OUP186; OUP 186.

IUPAC/Chemical Name: N-[4-(4-Chlorophenyl)butyl]-S-[(3-piperidin-1-yl)propyl]isothiourea

InChi Key: BEAOCYNTOAGFPE-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H30ClN3S/c20-18-10-8-17(9-11-18)7-2-3-12-22-19(21)24-16-6-15-23-13-4-1-5-14-23/h8-11H,1-7,12-16H2,(H2,21,22)

SMILES Code: N=C(NCCCCC1=CC=C(Cl)C=C1)SCCCN2CCCCC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 367.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tanaka S, Sakaguchi M, Yoneyama H, Usami Y, Harusawa S. Histamine H(3) receptor antagonist OUP-186 attenuates the proliferation of cultured human breast cancer cell lines. Biochem Biophys Res Commun. 2016 Nov 18;480(3):479-485. doi: 10.1016/j.bbrc.2016.10.077. Epub 2016 Oct 21. PubMed PMID: 27773822.

2: Yoneyama H, Yamamoto D, Yamatodani A, Harusawa S. Efficient Approaches to S-alkyl N-alkylisothioureas and Application to Novel Histamine H3R Antagonists. Yakugaku Zasshi. 2016;136(9):1217-32. doi: 10.1248/yakushi.16-00023. Review. PubMed PMID: 27592826.