WIN 64338 hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532971

CAS#: 163727-74-0

Description: WIN 64338 hydrochloride is a potent, non-peptide, competitive bradykinin B2 receptor antagonist.WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).

Price and Availability


USD 310


WIN 64338 hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 532971
Name: WIN 64338 hydrochloride
CAS#: 163727-74-0
Chemical Formula: C45H69Cl2N4OP
Exact Mass:
Molecular Weight: 783.95
Elemental Analysis: C, 68.95; H, 8.87; Cl, 9.04; N, 7.15; O, 2.04; P, 3.95

Related CAS #: 163727-74-0 (HCl)   151039-63-3(free)  

Synonym: WIN 64338 hydrochloride; WIN 64338 HCl; WIN 64338; WIN64338; WIN-64338.

IUPAC/Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride


InChi Code: InChI=1S/C45H67N4OP.2ClH/c1-4-7-30-51(31-8-5-2,32-9-6-3)35-36-25-28-42(29-26-36)46-44(50)43(34-37-24-27-38-18-16-17-19-39(38)33-37)49-45(47-40-20-12-10-13-21-40)48-41-22-14-11-15-23-41;;/h16-19,24-29,33,40-41,43H,4-15,20-23,30-32,34-35H2,1-3H3,(H2-,46,47,48,49,50);2*1H/t43-;;/m0../s1


Technical Data

White to off-white solid powder.

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Scherrer D, Schmidlin F, Lach E, Da Silva A, Landry Y, Gies JP. Effect of WIN 64338, a B2 bradykinin receptor antagonist on guinea-pig tracheal smooth muscle cells in culture. Fundam Clin Pharmacol. 1998;12(2):188-93. PubMed PMID: 9565773.

2: Hall JM, Figini M, Butt SK, Geppetti P. Inhibition of bradykinin-evoked trigeminal nerve stimulation by the non-peptide bradykinin B2 receptor antagonist WIN 64338 in vivo and in vitro. Br J Pharmacol. 1995 Dec;116(8):3164-8. PubMed PMID: 8719791; PubMed Central PMCID: PMC1909173.

3: Scherrer D, Daeffler L, Trifilieff A, Gies JP. Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br J Pharmacol. 1995 Aug;115(7):1127-8. PubMed PMID: 7582533; PubMed Central PMCID: PMC1908803.

4: Sawutz DG, Salvino JM, Dolle RE, Seoane PR, Farmer SG. Pharmacology and structure--activity relationships of the nonpeptide bradykinin receptor antagonist WIN 64338. Can J Physiol Pharmacol. 1995 Jul;73(7):805-11. Review. PubMed PMID: 8846413.

5: Wirth KJ, Schölkens BA, Wiemer G. The bradykinin B2 receptor antagonist WIN 64338 inhibits the effect of des-Arg9-bradykinin in endothelial cells. Eur J Pharmacol. 1994 Dec 15;288(1):R1-2. PubMed PMID: 7705460.

6: Sawutz DG, Salvino JM, Dolle RE, Casiano F, Ward SJ, Houck WT, Faunce DM, Douty BD, Baizman E, Awad MM, et al. The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4693-7. PubMed PMID: 8197121; PubMed Central PMCID: PMC43854.