WIN 64338 hydrochloride | CAS#163727-74-0 | CAS#151039-63-3 | Bradykinin Receptor Antagonist

WIN 64338 hydrochloride
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532971

CAS#: 163727-74-0

Description: WIN 64338 hydrochloride is a potent, non-peptide, competitive bradykinin B2 receptor antagonist.WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).

Chemical Structure

WIN 64338 hydrochloride

CAS# 163727-74-0

Instruction

Theoretical Analysis

MedKoo Cat#: 532971
Name: WIN 64338 hydrochloride
CAS#: 163727-74-0
Chemical Formula: C45H69Cl2N4OP
Exact Mass: 0.00
Molecular Weight: 783.950
Elemental Analysis: C, 68.95; H, 8.87; Cl, 9.04; N, 7.15; O, 2.04; P, 3.95

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 310
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 163727-74-0 (HCl) 151039-63-3(free)

Synonym: WIN 64338 hydrochloride; WIN 64338 HCl; WIN 64338; WIN64338; WIN-64338.

IUPAC/Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride

InChi Key: YYJGBEZPVOUBMJ-KRFCICRISA-N

InChi Code: InChI=1S/C45H67N4OP.2ClH/c1-4-7-30-51(31-8-5-2,32-9-6-3)35-36-25-28-42(29-26-36)46-44(50)43(34-37-24-27-38-18-16-17-19-39(38)33-37)49-45(47-40-20-12-10-13-21-40)48-41-22-14-11-15-23-41;;/h16-19,24-29,33,40-41,43H,4-15,20-23,30-32,34-35H2,1-3H3,(H2-,46,47,48,49,50);2*1H/t43-;;/m0../s1

SMILES Code: CCCC[P+](CCCC)(CC1=CC=C(NC([C@@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC=C5C=CC=CC5=C4)=O)C=C1)CCCC.[H]Cl.[Cl-]

Appearance: White to off-white solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 783.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Scherrer D, Schmidlin F, Lach E, Da Silva A, Landry Y, Gies JP. Effect of WIN 64338, a B2 bradykinin receptor antagonist on guinea-pig tracheal smooth muscle cells in culture. Fundam Clin Pharmacol. 1998;12(2):188-93. PubMed PMID: 9565773.

2: Hall JM, Figini M, Butt SK, Geppetti P. Inhibition of bradykinin-evoked trigeminal nerve stimulation by the non-peptide bradykinin B2 receptor antagonist WIN 64338 in vivo and in vitro. Br J Pharmacol. 1995 Dec;116(8):3164-8. PubMed PMID: 8719791; PubMed Central PMCID: PMC1909173.

3: Scherrer D, Daeffler L, Trifilieff A, Gies JP. Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br J Pharmacol. 1995 Aug;115(7):1127-8. PubMed PMID: 7582533; PubMed Central PMCID: PMC1908803.

4: Sawutz DG, Salvino JM, Dolle RE, Seoane PR, Farmer SG. Pharmacology and structure--activity relationships of the nonpeptide bradykinin receptor antagonist WIN 64338. Can J Physiol Pharmacol. 1995 Jul;73(7):805-11. Review. PubMed PMID: 8846413.

5: Wirth KJ, Schölkens BA, Wiemer G. The bradykinin B2 receptor antagonist WIN 64338 inhibits the effect of des-Arg9-bradykinin in endothelial cells. Eur J Pharmacol. 1994 Dec 15;288(1):R1-2. PubMed PMID: 7705460.

6: Sawutz DG, Salvino JM, Dolle RE, Casiano F, Ward SJ, Houck WT, Faunce DM, Douty BD, Baizman E, Awad MM, et al. The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4693-7. PubMed PMID: 8197121; PubMed Central PMCID: PMC43854.

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