VU0255035
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532900

CAS#: 1135243-19-4

Description: VU0255035 is a highly selective muscarinic M1 antagonist (Ki = 14.87 nM). VU0255035 targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes.

Chemical Structure

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VU0255035
CAS# 1135243-19-4
Instruction

Theoretical Analysis

MedKoo Cat#: 532900
Name: VU0255035
CAS#: 1135243-19-4
Chemical Formula: C18H20N6O3S2
Exact Mass: 432.10
Molecular Weight: 432.520
Elemental Analysis: C, 49.99; H, 4.66; N, 19.43; O, 11.10; S, 14.82

Price and Availability

Size Price Availability Quantity
5mg USD 280 2 Weeks
25mg USD 825 2 Weeks
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Synonym: VU0255035, VU 0255035, VU-0255035

IUPAC/Chemical Name: N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-7-sulfonamide

InChi Key: WXDHQWPQLKGANZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H20N6O3S2/c25-17(24-12-10-23(11-13-24)14-4-7-19-8-5-14)6-9-20-29(26,27)16-3-1-2-15-18(16)22-28-21-15/h1-5,7-8,20H,6,9-13H2

SMILES Code: O=S(C1=CC=CC2=NSN=C21)(NCCC(N3CCN(C4=CC=NC=C4)CC3)=O)=O

Appearance: Light yellow to yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 432.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Miller SL, Aroniadou-Anderjaska V, Pidoplichko VI, Figueiredo TH, Apland JP, Krishnan JK, Braga MF. The M1 Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala. J Pharmacol Exp Ther. 2017 Jan;360(1):23-32. Epub 2016 Oct 31. PubMed PMID: 27799295; PubMed Central PMCID: PMC5193080.