Cyanidin Chloride
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MedKoo CAT#: 525758

CAS#: 528-58-5

Description: Cyanidin Chloride is a blocker of the cytokine interleukin-17A binding to the IL-17RA subunit to alleviate inflammation in vivo.

Chemical Structure

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Cyanidin Chloride
CAS# 528-58-5
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 525758
Name: Cyanidin Chloride
CAS#: 528-58-5
Chemical Formula: C15H11ClO6
Exact Mass: 322.02
Molecular Weight: 322.697
Elemental Analysis: C, 55.83; H, 3.44; Cl, 10.99; O, 29.75

Price and Availability

Size Price Availability Quantity
5mg USD 215
10mg USD 390
25mg USD 650
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Synonym: Cyanidin Chloride

IUPAC/Chemical Name: 2-(3,4-Dihydroxyphenyl)chromenylium-3,5,7-triol chloride

InChi Key: COAWNPJQKJEHPG-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10O6.ClH/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-6H,(H4-,16,17,18,19,20);1H

SMILES Code: OC1=C(C2=CC=C(O)C(O)=C2)[O+]=C3C=C(O)C=C(O)C3=C1.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties.
In vitro activity: The effect of C3G (cyanidin-3-glucoside) on the viability of H1299, A549, and BEAS-2B cells was assessed by using the CCK-8 assay. As seen in Fig. 1A and B, cell viability was markedly reduced in C3G 10-, 20-, 40-, and 80-μM groups in both H1299 and A549 cells and in a dose-dependent manner (P < 0.05, P < 0.01). Reference: World J Surg Oncol. 2021 Aug 6;19(1):232. https://pubmed.ncbi.nlm.nih.gov/34362378/
In vivo activity: In As depicted in Figure 2B, compared to PCL group, the rats in the three cyan (cyaniding) groups exhibited a significant decrease in serum total bilirubin. Reference: World J Gastroenterol. 2021 Apr 14; 27(14): 1435–1450. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047539/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.5 63.53
DMF 25.0 77.47
DMF:PBS (pH 7.2) (1:9) 0.1 0.31
Ethanol 16.0 49.58

Preparing Stock Solutions

The following data is based on the product molecular weight 322.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Chen X, Zhang W, Xu X. Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway. World J Surg Oncol. 2021 Aug 6;19(1):232. doi: 10.1186/s12957-021-02339-7. PMID: 34362378; PMCID: PMC8348822. 2. Samarpita S, Rasool M. Cyanidin attenuates IL-17A cytokine signaling mediated monocyte migration and differentiation into mature osteoclasts in rheumatoid arthritis. Cytokine. 2021 Jun;142:155502. doi: 10.1016/j.cyto.2021.155502. Epub 2021 Mar 31. PMID: 33810944. 3. Matboli M, Hasanin AH, Hussein R, El-Nakeep S, Habib EK, Ellackany R, Saleh LA. Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion, in vivo study. World J Gastroenterol. 2021 Apr 14;27(14):1435-1450. doi: 10.3748/wjg.v27.i14.1435. PMID: 33911466; PMCID: PMC8047539. 4. Ouyang S, Chen W, Gaofeng Z, Changcheng L, Guoping T, Minyan Z, Yang L, Min Y, Luo J. Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF‑β1/p38 MAPK/CREB signaling pathway. Mol Med Rep. 2021 May;23(5):338. doi: 10.3892/mmr.2021.11977. Epub 2021 Mar 24. PMID: 33760143; PMCID: PMC7974420.
In vitro protocol: 1. Chen X, Zhang W, Xu X. Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway. World J Surg Oncol. 2021 Aug 6;19(1):232. doi: 10.1186/s12957-021-02339-7. PMID: 34362378; PMCID: PMC8348822. 2. Samarpita S, Rasool M. Cyanidin attenuates IL-17A cytokine signaling mediated monocyte migration and differentiation into mature osteoclasts in rheumatoid arthritis. Cytokine. 2021 Jun;142:155502. doi: 10.1016/j.cyto.2021.155502. Epub 2021 Mar 31. PMID: 33810944.
In vivo protocol: 1. Matboli M, Hasanin AH, Hussein R, El-Nakeep S, Habib EK, Ellackany R, Saleh LA. Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion, in vivo study. World J Gastroenterol. 2021 Apr 14;27(14):1435-1450. doi: 10.3748/wjg.v27.i14.1435. PMID: 33911466; PMCID: PMC8047539. 2. Ouyang S, Chen W, Gaofeng Z, Changcheng L, Guoping T, Minyan Z, Yang L, Min Y, Luo J. Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF‑β1/p38 MAPK/CREB signaling pathway. Mol Med Rep. 2021 May;23(5):338. doi: 10.3892/mmr.2021.11977. Epub 2021 Mar 24. PMID: 33760143; PMCID: PMC7974420.

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10: Rugină D, Hanganu D, Diaconeasa Z, Tăbăran F, Coman C, Leopold L, Bunea A, Pintea A. Antiproliferative and Apoptotic Potential of Cyanidin-Based Anthocyanins on Melanoma Cells. Int J Mol Sci. 2017 Apr 30;18(5). pii: E0949. doi: 10.3390/ijms18050949. PubMed PMID: 28468289.

11: Wang Y, Kim HJ, Sparrow JR. Quercetin and cyanidin-3-glucoside protect against photooxidation and photodegradation of A2E in retinal pigment epithelial cells. Exp Eye Res. 2017 Apr 28;160:45-55. doi: 10.1016/j.exer.2017.04.010. [Epub ahead of print] PubMed PMID: 28461203.

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17: Petroni K, Trinei M, Fornari M, Calvenzani V, Marinelli A, Micheli LA, Pilu R, Matros A, Mock HP, Tonelli C, Giorgio M. Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice. Nutr Metab Cardiovasc Dis. 2017 May;27(5):462-469. doi: 10.1016/j.numecd.2017.02.002. Epub 2017 Feb 21. PubMed PMID: 28428026.

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20: Sgherri C, Pérez-López U, Micaelli F, Miranda-Apodaca J, Mena-Petite A, Muñoz-Rueda A, Quartacci MF. Elevated CO(2) and salinity are responsible for phenolics-enrichment in two differently pigmented lettuces. Plant Physiol Biochem. 2017 Apr 7;115:269-278. doi: 10.1016/j.plaphy.2017.04.006. [Epub ahead of print] PubMed PMID: 28411511.