IWP-L6
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407489

CAS#: 1427782-89-5

Description: IWP-L6, also known as PORCN Inhibitor III and Wnt Pathway Inhibitor XIX, is a potent inhibitor of PORCN (EC50 = 0.5 nM). Porcupine is a member of the membrane-bound O-acyltransferase family of proteins. It catalyzes the palmitoylation of Wnt proteins, a process required for their secretion and activity.

Chemical Structure

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IWP-L6
CAS# 1427782-89-5
Instruction

Theoretical Analysis

MedKoo Cat#: 407489
Name: IWP-L6
CAS#: 1427782-89-5
Chemical Formula: C25H20N4O2S2
Exact Mass: 472.10
Molecular Weight: 472.581
Elemental Analysis: C, 63.54; H, 4.27; N, 11.86; O, 6.77; S, 13.57

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
100mg USD 1250 2 Weeks
200mg USD 2050 2 Weeks
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Synonym: IWP-L6; IWP L6; IWPL6; PORCN Inhibitor III; Wnt Pathway Inhibitor XIX.

IUPAC/Chemical Name: N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

InChi Key: QESQGTFWEQMCMH-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30)

SMILES Code: O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 472.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: You L, Zhang C, Yarravarapu N, Morlock L, Wang X, Zhang L, Williams NS, Lum L,
Chen C. Development of a triazole class of highly potent Porcn inhibitors. Bioorg
Med Chem Lett. 2016 Dec 15;26(24):5891-5895. doi: 10.1016/j.bmcl.2016.11.012.
Epub 2016 Nov 11. PubMed PMID: 27876319; PubMed Central PMCID: PMC5142825.


2: Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H,
Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. The development of highly
potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56(6):2700-4. doi:
10.1021/jm400159c. Epub 2013 Mar 19. PubMed PMID: 23477365; PubMed Central PMCID:
PMC3631274.


3: Gao X, Hannoush RN. Single-cell imaging of Wnt palmitoylation by the
acyltransferase porcupine. Nat Chem Biol. 2014 Jan;10(1):61-8. doi:
10.1038/nchembio.1392. Epub 2013 Nov 24. PubMed PMID: 24292069.