SSR 146977

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532793

CAS#: 264618-44-2

Description: SSR 146977 is a new potent nonpeptide tachykinin NK3 receptor antagonist.

Chemical Structure

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SSR 146977
CAS# 264618-44-2
Instruction

Theoretical Analysis

MedKoo Cat#: 532793
Name: SSR 146977
CAS#: 264618-44-2
Chemical Formula: C35H42Cl2N4O2
Exact Mass: 620.27
Molecular Weight: 621.650
Elemental Analysis: C, 67.62; H, 6.81; Cl, 11.41; N, 9.01; O, 5.15

Price and Availability

Size Price Availability Quantity
10mg USD 360
50mg USD 1030
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Synonym: SSR 146977; SSR146977; SSR-146977.

IUPAC/Chemical Name: 3-[1-[3-[(3R)-1-(benzoyl)-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-1,1-dimethylurea

InChi Key: XWPBINGFFFZAOZ-UMSFTDKQSA-N

InChi Code: InChI=1S/C35H42Cl2N4O2/c1-39(2)33(43)38-35(28-13-7-4-8-14-28)19-23-40(24-20-35)21-9-17-34(29-15-16-30(36)31(37)25-29)18-10-22-41(26-34)32(42)27-11-5-3-6-12-27/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3,(H,38,43)/t34-/m0/s1

SMILES Code: O=C(NC1(C2=CC=CC=C2)CCN(CCC[C@@]3(C4=CC=C(Cl)C(Cl)=C4)CN(C(C5=CC=CC=C5)=O)CCC3)CC1)N(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 621.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Anderson W, Newson P, Skeri M, Janssen N, Milne S, Yip J, Jungnickel S, Lynch-Frame A, Chahl LA. Effect of subchronic administration of tachykinin antagonists on response of guinea-pigs to mild and severe stress. Regul Pept. 2011 Jun 7;168(1-3):59-68. doi: 10.1016/j.regpep.2011.03.006. Epub 2011 Apr 13. PubMed PMID: 21477621.

2: Emonds-Alt X, Proietto V, Steinberg R, Advenier C, Daoui S, Naline E, Gueudet C, Michaud JC, Oury-Donat F, Poncelet M, Vilain P, Le Fur G, Maffrand JP, Soubrié P, Pascal M. Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can J Physiol Pharmacol. 2002 May;80(5):482-8. PubMed PMID: 12056557.