SR120819A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532786

CAS#: NA

Description: SR120819A is an orally-active and selective neuropeptide Y Y1 receptor antagonist.


Chemical Structure

img
SR120819A
CAS# NA

Theoretical Analysis

MedKoo Cat#: 532786
Name: SR120819A
CAS#: NA
Chemical Formula: C43H54N6O4S
Exact Mass: 750.39
Molecular Weight: 751.000
Elemental Analysis: C, 68.77; H, 7.25; N, 11.19; O, 8.52; S, 4.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SR120819A; SR 120819A; SR-120819A.

IUPAC/Chemical Name: (R)-N-((R)-3-(4-((Z)-N'-(((1s,4S)-4-((dimethylamino)methyl)cyclohexyl)methyl)carbamimidoyl)phenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-2-(naphthalene-2-sulfonamido)-3-phenylpropanamide

InChi Key: GKKPXBHNFVDHAQ-GWOGJWAKSA-N

InChi Code: InChI=1S/C43H54N6O4S/c1-48(2)30-34-16-14-33(15-17-34)29-45-41(44)36-20-18-32(19-21-36)27-40(43(51)49-24-8-9-25-49)46-42(50)39(26-31-10-4-3-5-11-31)47-54(52,53)38-23-22-35-12-6-7-13-37(35)28-38/h3-7,10-13,18-23,28,33-34,39-40,47H,8-9,14-17,24-27,29-30H2,1-2H3,(H2,44,45)(H,46,50)/t33-,34+,39-,40-/m1/s1

SMILES Code: O=C(N[C@H](CC1=CC=C(/C(N)=N/C[C@H]2CC[C@@H](CN(C)C)CC2)C=C1)C(N3CCCC3)=O)[C@H](NS(=O)(C4=CC=C5C=CC=CC5=C4)=O)CC6=CC=CC=C6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 751.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Sjödin P, Holmberg SK, Akerberg H, Berglund MM, Mohell N, Larhammar D. Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study. Biochem J. 2006 Jan 1;393(Pt 1):161-9. Erratum in: Biochem J. 2006 Sep 15;398(3):613. PubMed PMID: 16097949; PubMed Central PMCID: PMC1383674.

2: Holmberg SK, Mikko S, Boswell T, Zoorob R, Larhammar D. Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5. J Neurochem. 2002 May;81(3):462-71. PubMed PMID: 12065655.

3: Berglund MM, Lundell I, Cabrele C, Serradeil-Le Gal C, Beck-Sickinger AG, Larhammar D. Binding properties of three neuropeptide Y receptor subtypes from zebrafish: comparison with mammalian Y1 receptors. Biochem Pharmacol. 2000 Dec 15;60(12):1815-22. PubMed PMID: 11108796.

4: Serradeil-Le Gal C, Lafontan M, Raufaste D, Marchand J, Pouzet B, Casellas P, Pascal M, Maffrand JP, Le Fur G. Characterization of NPY receptors controlling lipolysis and leptin secretion in human adipocytes. FEBS Lett. 2000 Jun 16;475(2):150-6. PubMed PMID: 10858507.

5: Sun L, Philipson LH, Miller RJ. Regulation of K+ and Ca++ channels by a family of neuropeptide Y receptors. J Pharmacol Exp Ther. 1998 Feb;284(2):625-32. PubMed PMID: 9454807.