CS-526

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528521

CAS#: 313272-12-7

Description: CS-526, also known as R-105266, is a proton pump inhibitor potentially for treatment of gastric ulcer. CS-526 has a potent antisecretory effect on gastric acid secretion without rebound gastric hypersecretion. The inhibitory mechanism of CS-526 on H+,K+-ATPase was a competitive antagonism to the K+ binding site of H+,K+-ATPase, and it was also a reversible inhibition. CS-526 inhibited acute gastric mucosal lesions. CS-526 inhibited histamine-stimulated gastric acid secretion in a dose- and retention time-dependent manner.

Chemical Structure

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CS-526
CAS# 313272-12-7
Instruction

Theoretical Analysis

MedKoo Cat#: 528521
Name: CS-526
CAS#: 313272-12-7
Chemical Formula: C20H22FN3O
Exact Mass: 339.17
Molecular Weight: 339.414
Elemental Analysis: C, 70.77; H, 6.53; F, 5.60; N, 12.38; O, 4.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CS-526; CS 526; CS526; R-105266; R 105266; R105266

IUPAC/Chemical Name: 7-((4-fluorobenzyl)oxy)-2,3-dimethyl-1-(((1S,2S)-2-methylcyclopropyl)methyl)-1H-pyrrolo[2,3-d]pyridazine

InChi Key: NXPLYKRKIFPEOA-BLLLJJGKSA-N

InChi Code: InChI=1S/C20H22FN3O/c1-12-8-16(12)10-24-14(3)13(2)18-9-22-23-20(19(18)24)25-11-15-4-6-17(21)7-5-15/h4-7,9,12,16H,8,10-11H2,1-3H3/t12-,16+/m0/s1

SMILES Code: C[C@@H]1[C@@H](CN2C(C)=C(C)C3=C2C(OCC4=CC=C(F)C=C4)=NN=C3)C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 339.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: De Luca L, Olivari Z, Farina A, Gonzini L, Lucci D, Di Chiara A, Casella G, Chiarella F, Boccanelli A, Di Pasquale G, De Servi S, Bovenzi FM, Gulizia MM, Savonitto S. Temporal trends in the epidemiology, management, and outcome of patients with cardiogenic shock complicating acute coronary syndromes. Eur J Heart Fail. 2015 Nov;17(11):1124-32. doi: 10.1002/ejhf.339. Epub 2015 Sep 4. PubMed PMID: 26339723.

2: Ito K, Kinoshita K, Yamamura N, Tomizawa A, Inaba F, Morikawa-Inomata Y, Tabata K, Shibakawa N. Pharmacodynamic and pharmacokinetic evaluation of CS-526 in cynomolgus monkeys. Biol Pharm Bull. 2009 Dec;32(12):2010-7. PubMed PMID: 19952420.

3: Ito K, Kinoshita K, Tomizawa A, Morikawa-Inomata Y, Inaba F, Fujita Y, Tabata K, Shibakawa N. The effect of subchronic administration of 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyr rolo[2,3-d]pyridazine (CS-526), a novel acid pump antagonist, on gastric acid secretion and gastrin levels in rats. J Pharmacol Exp Ther. 2008 Jul;326(1):163-70. doi: 10.1124/jpet.108.137299. Epub 2008 Apr 14. PubMed PMID: 18411413.

4: Ito K, Kinoshita K, Tomizawa A, Inaba F, Morikawa-Inomata Y, Makino M, Tabata K, Shibakawa N. Pharmacological profile of novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526). J Pharmacol Exp Ther. 2007 Oct;323(1):308-17. Epub 2007 Jul 13. PubMed PMID: 17630360.