CP-424174
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530552

CAS#: 210825-31-3

Description: CP-424174 is a cytokine release inhibitory drug (CRID) (IC50 = 210 nM).CP-424174 inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes.

Chemical Structure

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CP-424174
CAS# 210825-31-3
Instruction

Theoretical Analysis

MedKoo Cat#: 530552
Name: CP-424174
CAS#: 210825-31-3
Chemical Formula: C22H29ClN2O4S
Exact Mass: 452.15
Molecular Weight: 452.994
Elemental Analysis: C, 58.33; H, 6.45; Cl, 7.83; N, 6.18; O, 14.13; S, 7.08

Price and Availability

Size Price Availability Quantity
10mg USD 300 2 Weeks
25mg USD 580 2 Weeks
50mg USD 945 2 Weeks
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Synonym: CP-424174; CP 424174; CP424174; CP-424,174; CP 424,174; CP424,174.

IUPAC/Chemical Name: N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide

InChi Key: YRSBLSHMKVQWHP-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H29ClN2O4S/c1-13(2)18-11-16(23)12-19(14(3)4)20(18)24-21(26)25-30(28,29)17-9-7-8-15(10-17)22(5,6)27/h7-14,27H,1-6H3,(H2,24,25,26)

SMILES Code: O=S(C1=CC=CC(C(C)(O)C)=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 452.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Perregaux DG, McNiff P, Laliberte R, Hawryluk N, Peurano H, Stam E, Eggler J,
Griffiths R, Dombroski MA, Gabel CA. Identification and characterization of a
novel class of interleukin-1 post-translational processing inhibitors. J
Pharmacol Exp Ther. 2001 Oct;299(1):187-97. PubMed PMID: 11561079.


2: Perregaux DG, Bhavsar K, Contillo L, Shi J, Gabel CA. Antimicrobial peptides
initiate IL-1 beta posttranslational processing: a novel role beyond innate
immunity. J Immunol. 2002 Mar 15;168(6):3024-32. PubMed PMID: 11884475.