GSK-319347A
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407415

CAS#: 862812-98-4

Description: GSK-319347A is a potent and selective IKKε inhibitor (pIC50 = 7.4). GSK-319347A has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.

Chemical Structure

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GSK-319347A
CAS# 862812-98-4
Instruction

Theoretical Analysis

MedKoo Cat#: 407415
Name: GSK-319347A
CAS#: 862812-98-4
Chemical Formula: C22H19N3O5S2
Exact Mass: 469.08
Molecular Weight: 469.530
Elemental Analysis: C, 56.28; H, 4.08; N, 8.95; O, 17.04; S, 13.66

Price and Availability

Size Price Availability Quantity
5mg USD 450 2 Weeks
10mg USD 800 2 Weeks
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Synonym: GSK-319347A; GSK-319347A; GSK-319347A;

IUPAC/Chemical Name: 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile

InChi Key: LDTAHRLHGHFHKP-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3

SMILES Code: N#CC1=C(OCC2=CC=CC=C2S(=O)(C)=O)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 469.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bamborough P, Christopher JA, Cutler GJ, Dickson MC, Mellor GW, Morey JV,
Patel CB, Shewchuk LM. 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles
as potent, selective, inhibitors of IKK-epsilon kinase. Bioorg Med Chem Lett.
2006 Dec 15;16(24):6236-40. PubMed PMID: 16997559.