GPP78
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MedKoo CAT#: 407399

CAS#: 1202580-59-3

Description: GPP78, also known as CAY10618, is a NMPRTase Inhibitor. The inhibition of NAD synthesis or salvage pathways has been proposed as a novel target for antitumoral drugs. GPP78 displays an IC(50) for cytotoxicity in vitro of 3.8 +/- 0.3 nM and an IC(50) for NAD depletion of 3.0 +/- 0.4 nM.

Chemical Structure

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GPP78
CAS# 1202580-59-3
Instruction

Theoretical Analysis

MedKoo Cat#: 407399
Name: GPP78
CAS#: 1202580-59-3
Chemical Formula: C27H29N5O
Exact Mass: 439.24
Molecular Weight: 439.563
Elemental Analysis: C, 73.78; H, 6.65; N, 15.93; O, 3.64

Price and Availability

Size Price Availability Quantity
5mg USD 270
10mg USD 460
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Synonym: GPP78; GPP-78; GPP 78; CAY10618; CAY-10618; CAY 10618.

IUPAC/Chemical Name: N-([1,1'-biphenyl]-2-yl)-8-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)octanamide

InChi Key: SJOLTIOPWDLDEB-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H29N5O/c33-27(29-25-16-9-8-15-24(25)22-12-5-4-6-13-22)17-7-2-1-3-10-19-32-21-26(30-31-32)23-14-11-18-28-20-23/h4-6,8-9,11-16,18,20-21H,1-3,7,10,17,19H2,(H,29,33)

SMILES Code: O=C(NC1=C(C2=CC=CC=C2)C=CC=C1)CCCCCCCN3N=NC(C4=CC=CN=C4)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 439.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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