GSK579289A
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531884

CAS#: 929095-23-8

Description: GSK579289A is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM). It is selective for Plk1 over Plk3 (IC50 = 630 nM). GSK579289A inhibits proliferation of HCT116 cells (IC50 = 11 nM).

Chemical Structure

img
GSK579289A
CAS# 929095-23-8
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 531884
Name: GSK579289A
CAS#: 929095-23-8
Chemical Formula: C26H27ClN4O3S
Exact Mass: 510.15
Molecular Weight: 511.037
Elemental Analysis: C, 61.11; H, 5.33; Cl, 6.94; N, 10.96; O, 9.39; S, 6.27

Price and Availability

Size Price Availability Quantity
5mg USD 325 2 Weeks
10mg USD 585 2 Weeks
25mg USD 1050 2 Weeks
Bulk inquiry

Synonym: GSK579289A; GSK 579289A; GSK-579289A.

IUPAC/Chemical Name: 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-[6-(1-methylpiperidin-4-yl)oxybenzimidazol-1-yl]thiophene-2-carboxamide

InChi Key: GILNGUYOGYOZMP-MRXNPFEDSA-N

InChi Code: InChI=1S/C26H27ClN4O3S/c1-16(19-5-3-4-6-20(19)27)33-23-14-24(35-25(23)26(28)32)31-15-29-21-8-7-18(13-22(21)31)34-17-9-11-30(2)12-10-17/h3-8,13-17H,9-12H2,1-2H3,(H2,28,32)/t16-/m1/s1

SMILES Code: O=C(C1=C(O[C@@H](C2=CC=CC=C2Cl)C)C=C(N3C4=CC(OC5CCN(C)CC5)=CC=C4N=C3)S1)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: GSK579289A is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM).
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.0 48.92

Preparing Stock Solutions

The following data is based on the product molecular weight 511.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Long T, Neitz RJ, Beasley R, et al. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. Geary TG, ed. PLoS Neglected Tropical Diseases. 2016;10(1):e0004356. doi:10.1371/journal.pntd.0004356.