CP-775146
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531747

CAS#: 702680-17-9

Description: CP-775146 is a selective, high affinity PPARα agonist. CP-775146 exhibits hypolipidemic activity in vivo.

Chemical Structure

img
CP-775146
CAS# 702680-17-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 531747
Name: CP-775146
CAS#: 702680-17-9
Chemical Formula: C26H33NO4
Exact Mass: 423.24
Molecular Weight: 423.550
Elemental Analysis: C, 73.73; H, 7.85; N, 3.31; O, 15.11

Price and Availability

Size Price Availability Quantity
5mg USD 250 2 Weeks
10mg USD 450 2 Weeks
25mg USD 850 2 Weeks
Bulk inquiry

Synonym: CP-775146; CP 775146; CP775146.

IUPAC/Chemical Name: 2-methyl-2-[3-[(3S)-1-[2-(4-propan-2-ylphenyl)acetyl]piperidin-3-yl]phenoxy]propanoic acid

InChi Key: OISHBINQIFNIPV-JOCHJYFZSA-N

InChi Code: InChI=1S/C26H33NO4/c1-18(2)20-12-10-19(11-13-20)15-24(28)27-14-6-8-22(17-27)21-7-5-9-23(16-21)31-26(3,4)25(29)30/h5,7,9-13,16,18,22H,6,8,14-15,17H2,1-4H3,(H,29,30)/t22-/m1/s1

SMILES Code: CC(OC1=CC=CC([C@H]2CN(C(CC3=CC=C(C(C)C)C=C3)=O)CCC2)=C1)(C)C(O)=O

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Selective, high affinity PPARα agonist.
In vitro activity: TBD
In vivo activity: CP775146 increased the liver weight but did not affect the on mean body weight (Figures 1(a) and 1(b)). At >0.3 mg/kg, CP775146 significantly increased the serum alanine aminotransferase (ALT) level (a measure of liver function, Figure 1(c)) but not that of aspartate aminotransferase (AST, Figure 1(d)). Reference: J Diabetes Res. 2020; 2020: 4179852. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222497/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.4 99.99

Preparing Stock Solutions

The following data is based on the product molecular weight 423.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Tang S, Wu F, Lin X, Gui W, Zheng F, Li H. The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism. J Diabetes Res. 2020 May 4;2020:4179852. doi: 10.1155/2020/4179852. PMID: 32455134; PMCID: PMC7222497.
In vitro protocol: TBD
In vivo protocol: 1. Tang S, Wu F, Lin X, Gui W, Zheng F, Li H. The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism. J Diabetes Res. 2020 May 4;2020:4179852. doi: 10.1155/2020/4179852. PMID: 32455134; PMCID: PMC7222497.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Kane et al (2009) Molecular characterization of novel and selective peroxisome proliferator-activated receptor α agonists with robust hypolipidemic activity in vivo. Mol.Pharmacol. 75 296. PMID: 18971326.