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BTB06584
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530497

CAS#: 219793-45-0

Description: BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 inhibited F1 Fo-ATPase activity with no effect on ΔΨm or O2 consumption. BTB06584 efficiency was increased by IF1 overexpression and reduced by silencing the protein.BTB06584 may represent a valuable tool to selectively inhibit mitochondrial F1 Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATPsynthase.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 850 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2950 2 Weeks
2g USD 4650 2 Weeks
5g USD 6950 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-01-25. Prices are subject to change without notice.

BTB06584, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530497
Name: BTB06584
CAS#: 219793-45-0
Chemical Formula: C19H12ClNO6S
Exact Mass: 417.0074
Molecular Weight: 417.816
Elemental Analysis: C, 54.62; H, 2.90; Cl, 8.48; N, 3.35; O, 22.98; S, 7.67


Synonym: BTB06584; BTB-06584; BTB 06584.

IUPAC/Chemical Name: 2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate

InChi Key: WNDWKKPBLAKXMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H12ClNO6S/c20-14-8-6-13(7-9-14)19(22)27-18-12-16(10-11-17(18)21(23)24)28(25,26)15-4-2-1-3-5-15/h1-12H

SMILES Code: O=S(C1=CC(OC(C2=CC=C(Cl)C=C2)=O)=C([N+]([O-])=O)C=C1)(C3=CC=CC=C3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ivanes F, Faccenda D, Gatliff J, Ahmed AA, Cocco S, Cheng CH, Allan E, Russell
C, Duchen MR, Campanella M. The compound BTB06584 is an IF1 -dependent selective
inhibitor of the mitochondrial F1 Fo-ATPase. Br J Pharmacol. 2014
Sep;171(18):4193-206. doi: 10.1111/bph.12638. PubMed PMID: 24641180; PubMed
Central PMCID: PMC4241087.

2: Matic I, Strobbe D, Frison M, Campanella M. Controlled and Impaired
Mitochondrial Quality in Neurons: Molecular Physiology and Prospective
Pharmacology. Pharmacol Res. 2015 Sep;99:410-24. doi: 10.1016/j.phrs.2015.03.021.
Review. PubMed PMID: 25917207.