CGP53353
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 513675

CAS#: 145915-60-2

Description: CGP53353 is a selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). CGP53353 also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.

Chemical Structure

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CGP53353
CAS# 145915-60-2
Instruction

Theoretical Analysis

MedKoo Cat#: 513675
Name: CGP53353
CAS#: 145915-60-2
Chemical Formula: C20H13F2N3O2
Exact Mass: 365.10
Molecular Weight: 365.340
Elemental Analysis: C, 65.75; H, 3.59; F, 10.40; N, 11.50; O, 8.76

Price and Availability

Size Price Availability Quantity
25mg USD 350 2 Weeks
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 3650 2 Weeks
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Synonym: CGP53353; CGP 53353; CGP-53353.

IUPAC/Chemical Name: 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione

InChi Key: RONQPWQYDRPRGG-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27)

SMILES Code: O=C1NC(C2=C1C=C(NC3=CC=C(F)C=C3)C(NC4=CC=C(F)C=C4)=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 365.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Liu Y, Jin J, Qiao S, Lei S, Liao S, Ge ZD, Li H, Wong GT, Irwin MG, Xia Z. Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling. Clin Sci (Lond). 2015 Aug;129(4):331-44. doi: 10.1042/CS20140789. PubMed PMID: 25849791.

2: Zhu M, Chen J, Wen M, Sun Z, Sun X, Wang J, Miao C. Propofol protects against angiotensin II-induced mouse hippocampal HT22 cells apoptosis via inhibition of p66Shc mitochondrial translocation. Neuromolecular Med. 2014 Dec;16(4):772-81. doi: 10.1007/s12017-014-8326-6. PubMed PMID: 25151272.