CGP 35348

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 513669

CAS#: 123690-79-9

Description: CGP 35348 is a selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). CGP 35348 has a higher affinity for postsynaptic versus presynaptic receptors.

Chemical Structure

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CGP 35348
CAS# 123690-79-9
Instruction

Theoretical Analysis

MedKoo Cat#: 513669
Name: CGP 35348
CAS#: 123690-79-9
Chemical Formula: C8H20NO4P
Exact Mass: 225.11
Molecular Weight: 225.220
Elemental Analysis: C, 42.66; H, 8.95; N, 6.22; O, 28.41; P, 13.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CGP 35348; CGP35348; CGP-35348.

IUPAC/Chemical Name: 3-aminopropyl-(diethoxymethyl)phosphinic acid

InChi Key: QIIVUOWTHWIXFO-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)

SMILES Code: O=P(C(OCC)OCC)(CCCN)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 225.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gillani Q, Ali M, Iqbal F. Effect of GABA(B) receptor antagonists (CGP 35348 and CGP 55845) on serum interleukin 6 and 18 concentrations in albino mice following neonatal hypoxia ischemia insult. Pak J Pharm Sci. 2016 Sep;29(5):1503-1508. PubMed PMID: 27731803.

2: Gillani Q, Ali M, Iqbal F. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215. doi: 10.1155/2014/295215. PubMed PMID: 24804211; PubMed Central PMCID: PMC3997133.

3: Mareš P. GABA-B receptor antagonist CGP 35348 interferes with an arrest of cortical epileptic afterdischarges in developing rats. Epilepsy Res. 2010 Dec;92(2-3):125-33. doi: 10.1016/j.eplepsyres.2010.08.011. PubMed PMID: 20863662.

4: Patel SM, Ebenezer IS. The effects of intraperitoneal and intracerebroventricular administration of the GABAB receptor antagonist CGP 35348 on food intake in rats. Eur J Pharmacol. 2004 Oct 25;503(1-3):89-93. PubMed PMID: 15496301.

5: Ritchie GD, Hulme ME, Rossi J 3rd. Treatment of spontaneous and chemically induced EEG paroxysms in the Fischer-344 rat with traditional antiepileptic drugs or AED+CGP 35348 polytherapy. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Aug;27(5):847-62. PubMed PMID: 12921919.

6: Vinay L, Clarac F. CGP 35348 and CGP 55845A block the baclofen-induced depression of dorsal root evoked potentials in lumbar motoneurons of the neonatal rat. Neurosci Lett. 1996 Aug 23;214(2-3):103-6. PubMed PMID: 8878094.

7: Smith KA, Fisher RS. The selective GABAB antagonist CGP-35348 blocks spike-wave bursts in the cholesterol synthesis rat absence epilepsy model. Brain Res. 1996 Aug 12;729(2):147-50. PubMed PMID: 8876982.

8: Thomas DA, Navarrete IM, Graham BA, McGowan MK, Hammond DL. Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats. Brain Res. 1996 Apr 29;718(1-2):129-37. PubMed PMID: 8773775.

9: Nissbrandt H, Engberg G. The GABAB-receptor antagonist, CGP 35348, antagonises gamma-hydroxybutyrate- and baclofen-induced alterations in locomotor activity and forebrain dopamine levels in mice. J Neural Transm (Vienna). 1996;103(11):1255-63. PubMed PMID: 9013412.

10: Puigcerver A, van Luijtelaar EL, Drinkenburg WH, Coenen AL. Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats. Brain Res Bull. 1996;40(3):157-62. PubMed PMID: 8736575.

11: Chowdhury SA, Kawashima T, Konishi T, Niwa M, Matsunami K. GABAB receptor antagonist CGP 35348 shortens transcallosal response latency of pyramidal tract neurons. Eur J Pharmacol. 1995 Oct 4;285(1):99-102. PubMed PMID: 8846817.

12: Niklasson M, Stengård K, Tham R. Are the effects of toluene on the vestibulo and opto-ocular motor system inhibited by the action of GABAB antagonist CGP 35348? Neurotoxicol Teratol. 1995 May-Jun;17(3):351-7. PubMed PMID: 7623742.

13: Paredes RG, Agmo A. The GABAB antagonist CGP 35348 inhibits the effects of baclofen on sexual behavior and motor coordination. Brain Res Bull. 1995;36(5):495-7. PubMed PMID: 7712213.

14: Hao JX, Xu XJ, Wiesenfeld-Hallin Z. Intrathecal gamma-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitivity to mechanical stimuli in the rat. Neurosci Lett. 1994 Dec 5;182(2):299-302. PubMed PMID: 7715832.

15: Schlicker E, Malinowska B, Kathmann M. CGP 35348 blocks noradrenaline-release-inhibiting GABAB receptors in the pig retina, rat vena cava and pithed rat vasculature. Pharmacology. 1993 Aug;47(2):111-6. PubMed PMID: 8395059.

16: Hammond DL, Washington JD. Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat. Eur J Pharmacol. 1993 Apr 6;234(2-3):255-62. PubMed PMID: 8387011.

17: Bianchi M, Panerai AE. Reversal of scopolamine-induced amnesia by the GABAB receptor antagonist CGP 35348 in the mouse. Brain Res Cogn Brain Res. 1993 Apr;1(2):135-6. PubMed PMID: 8390321.

18: Brucato FH, Morrisett RA, Wilson WA, Swartzwelder HS. The GABAB receptor antagonist, CGP-35348, inhibits paired-pulse disinhibition in the rat dentate gyrus in vivo. Brain Res. 1992 Aug 14;588(1):150-3. PubMed PMID: 1327407.

19: Malcangio M, Malmberg-Aiello P, Giotti A, Ghelardini C, Bartolini A. Desensitization of GABAB receptors and antagonism by CGP 35348, prevent bicuculline- and picrotoxin-induced antinociception. Neuropharmacology. 1992 Aug;31(8):783-91. PubMed PMID: 1326728.

20: Waldmeier PC, Stöcklin K, Feldtrauer JJ. Systemic administration of baclofen and the GABAB antagonist, CGP 35348, does not affect GABA, glutamate or aspartate in microdialysates of the striatum of conscious rats. Naunyn Schmiedebergs Arch Pharmacol. 1992 May;345(5):548-52. PubMed PMID: 1356233.