NS-638 | CAS#150493-34-8 | Ca(2+)-channel blocker

NS-638
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530468

CAS#: 150493-34-8

Description: NS-638 is a Ca(2+)-channel blocker. NS-638 dose dependently inhibited K(+)-stimulated [45Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 microM, respectively. K(+)-stimulated intracellular Ca(2+)-elevation in cultured cerebellar granule cells was equipotently blocked with an IC50 value of 3.4 microM.

Chemical Structure

NS-638

CAS# 150493-34-8

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 530468
Name: NS-638
CAS#: 150493-34-8
Chemical Formula: C15H11ClF3N3
Exact Mass: 325.06
Molecular Weight: 325.719
Elemental Analysis: C, 55.31; H, 3.40; Cl, 10.88; F, 17.50; N, 12.90

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 750
200mg	USD 1250
500mg	USD 1950
1g	USD 2850
2g	USD 3850
5g	USD 5750
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NS-638; NS 638; NS638.

IUPAC/Chemical Name: 2-Amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

InChi Key: GXQCVUZORDAARJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H11ClF3N3/c16-11-4-1-9(2-5-11)8-22-13-6-3-10(15(17,18)19)7-12(13)21-14(22)20/h1-7H,8H2,(H2,20,21)

SMILES Code: FC(C1=CC=C2C(N=C(N)N2CC3=CC=C(Cl)C=C3)=C1)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties.
In vitro activity:	NS-638 dose dependently inhibited K(+)-stimulated [45Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 microM, respectively. Reference: Neurol Res. 1995 Oct;17(5):353-60. https://pubmed.ncbi.nlm.nih.gov/8584126/
In vivo activity:	In the mouse middle cerebral artery occlusion (MCAO) model, NS-638 administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, resulted in a 48% reduction in total infarct volume. Reference: Neurol Res. 1995 Oct;17(5):353-60. https://pubmed.ncbi.nlm.nih.gov/8584126/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.5	59.87
	Ethanol	2.0	6.14

Preparing Stock Solutions

The following data is based on the product molecular weight 325.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	Møller A, Christophersen P, Drejer J, Axelsson O, Peters D, Jensen LH, Nielsen EO. Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638. Neurol Res. 1995 Oct;17(5):353-60. PMID: 8584126.
In vitro protocol:	Møller A, Christophersen P, Drejer J, Axelsson O, Peters D, Jensen LH, Nielsen EO. Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638. Neurol Res. 1995 Oct;17(5):353-60. PMID: 8584126.
In vivo protocol:	NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties.

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1: Møller A, Christophersen P, Drejer J, Axelsson O, Peters D, Jensen LH, Nielsen
EO. Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel
blocker NS-638. Neurol Res. 1995 Oct;17(5):353-60. PubMed PMID: 8584126.

2: Olesen SP, Møller A, Mordvintcev PI, Busse R, Mülsch A. Regional measurements
of NO formed in vivo during brain ischemia. Acta Neurol Scand. 1997
Apr;95(4):219-24. PubMed PMID: 9150812.

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