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MedKoo CAT#: 530468

CAS#: 150493-34-8

Description: NS-638 is a Ca(2+)-channel blocker. NS-638 dose dependently inhibited K(+)-stimulated [45Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 microM, respectively. K(+)-stimulated intracellular Ca(2+)-elevation in cultured cerebellar granule cells was equipotently blocked with an IC50 value of 3.4 microM.

Price and Availability

Size Price Shipping out time Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2850 2 Weeks
2g USD 3850 2 Weeks
5g USD 5750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-03. Prices are subject to change without notice.

NS-638, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530468
Name: NS-638
CAS#: 150493-34-8
Chemical Formula: C15H11ClF3N3
Exact Mass: 325.0594
Molecular Weight: 325.7192
Elemental Analysis: C, 55.31; H, 3.40; Cl, 10.88; F, 17.50; N, 12.90

Synonym: NS-638; NS 638; NS638.

IUPAC/Chemical Name: 2-Amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole


InChi Code: InChI=1S/C15H11ClF3N3/c16-11-4-1-9(2-5-11)8-22-13-6-3-10(15(17,18)19)7-12(13)21-14(22)20/h1-7H,8H2,(H2,20,21)

SMILES Code: FC(C1=CC=C2C(N=C(N)N2CC3=CC=C(Cl)C=C3)=C1)(F)F

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Møller A, Christophersen P, Drejer J, Axelsson O, Peters D, Jensen LH, Nielsen
EO. Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel
blocker NS-638. Neurol Res. 1995 Oct;17(5):353-60. PubMed PMID: 8584126.

2: Olesen SP, Møller A, Mordvintcev PI, Busse R, Mülsch A. Regional measurements
of NO formed in vivo during brain ischemia. Acta Neurol Scand. 1997
Apr;95(4):219-24. PubMed PMID: 9150812.