SU 5205 | CAS#3476-86-6 | VEGFR2 inhibitor

SU 5205
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531310

CAS#: 3476-86-6

Description: SU 5205 is a VEGFR2 inhibitor.

Chemical Structure

SU 5205

CAS# 3476-86-6

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 531310
Name: SU 5205
CAS#: 3476-86-6
Chemical Formula: C15H10FNO
Exact Mass: 239.07
Molecular Weight: 239.250
Elemental Analysis: C, 75.30; H, 4.21; F, 7.94; N, 5.85; O, 6.69

Price and Availability

Size	Price	Availability
100mg	USD 200	2 Weeks
200mg	USD 350	2 Weeks
500mg	USD 750	2 Weeks
1g	USD 1350	2 Weeks
2g	USD 2350	2 Weeks
5g	USD 4250	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: SU 5205; SU-5205; SU5205.

IUPAC/Chemical Name: 2-Indolinone, 3-(p-fluorobenzylidene)-

InChi Key: QIERHADIMMFZNE-LCYFTJDESA-N

InChi Code: InChI=1S/C15H10FNO/c16-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)17-15(13)18/h1-9H,(H,17,18)/b13-9-

SMILES Code: O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(F)C=C3

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	SU 5205 is an inhibitor of VEGFR2 (FLK-1), with an IC50 of 9.6 μM.
In vitro activity:	To be determined
In vivo activity:	To be determined

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	250.0	1,044.98

Preparing Stock Solutions

The following data is based on the product molecular weight 239.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	To be determined
In vitro protocol:	To be determined
In vivo protocol:	To be determined

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Tian XF, Huang GM, Zang HL, Cao H. PACE4 regulates apoptosis in human pancreatic cancer Panc 1 cells via the mitochondrial signaling pathway. Mol Med Rep. 2016 Dec;14(6):5205-5210. doi: 10.3892/mmr.2016.5885. PubMed PMID: 27779720.

2: Tanaka S, Kaneko H, Kano H, Matsuno S, Suzuki S, Takai H, Otsuka T, Uejima T, Oikawa Y, Nagashima K, Kirigaya H, Sagara K, Yajima J, Sawada H, Aizawa T, Yamashita T. The predictive value of the borderline ankle-brachial index for long-term clinical outcomes: An observational cohort study. Atherosclerosis. 2016 Jul;250:69-76. doi: 10.1016/j.atherosclerosis.2016.05.014. PubMed PMID: 27182960.

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6: Brunocilla E, Gentile G, Schiavina R, Borghesi M, Franceschelli A, Pultrone CV, Chessa F, Romagnoli D, Ghanem SM, Gacci M, Martorana G, Colombo F. Testis-sparing surgery for the conservative management of small testicular masses: an update. Anticancer Res. 2013 Nov;33(11):5205-10. Review. PubMed PMID: 24222171.

7: Almesbah F, Mandiwanza T, Kaliaperumal C, Caird J, Crimmins D. Routine preoperative blood testing in pediatric neurosurgery. J Neurosurg Pediatr. 2013 Dec;12(6):615-21. doi: 10.3171/2013.8.PEDS13254. PubMed PMID: 24093590.

8: Kooby DA, Gillespie TW, Liu Y, Byrd-Sellers J, Landry J, Bian J, Lipscomb J. Impact of adjuvant radiotherapy on survival after pancreatic cancer resection: an appraisal of data from the national cancer data base. Ann Surg Oncol. 2013 Oct;20(11):3634-42. doi: 10.1245/s10434-013-3047-x. PubMed PMID: 23771249; PubMed Central PMCID: PMC4868076.

9: Liang YL, Yu YC, Liu K, Wang WJ, Ying JB, Wang YF, Cai XJ. Repair of bile duct defect with degradable stent and autologous tissue in a porcine model. World J Gastroenterol. 2012 Oct 7;18(37):5205-10. doi: 10.3748/wjg.v18.i37.5205. PubMed PMID: 23066314; PubMed Central PMCID: PMC3468852.

10: Cosmatos I, Matcho A, Weinstein R, Montgomery MO, Stang P. Analysis of patient claims data to determine the prevalence of hidradenitis suppurativa in the United States. J Am Acad Dermatol. 2013 Mar;68(3):412-9. doi: 10.1016/j.jaad.2012.07.027. PubMed PMID: 22921795.

11: Lin F, Li Y, Cao J, Fan S, Wen J, Zhu G, Du H, Liang Y. Overexpression of osteopontin in hepatocellular carcinoma and its relationships with metastasis, invasion of tumor cells. Mol Biol Rep. 2011 Nov;38(8):5205-10. doi: 10.1007/s11033-010-0671-4. PubMed PMID: 21188534.

12: Zorn KC. Editorial comment re: Predictors of early urinary continence after robotic prostatectomy. Can J Urol. 2010 Jun;17(3):5205-6. PubMed PMID: 20566015.

13: van Isterdael CE, Stilma JS, Bezemer PD, Tijmes NT. [Determining factors for deciding whether or not to treat refractive errors and cataract in people with a learning disability]. Ned Tijdschr Geneeskd. 2008 May 3;152(18):1048-51. Dutch. PubMed PMID: 18547027.

14: Poma PA, Barber A. Fallopian tube necrosis after postpartum sterilization. J Natl Med Assoc. 2001 Apr;93(4):149-50. PubMed PMID: 12653402; PubMed Central PMCID: PMC2593986.

15: Erikson J. Fisher given new role in cancer project. Science. 1995 Mar 24;267(5205):1762. PubMed PMID: 7892594.

16: Bereznitskiĭ IaS, Ruban VM, Spivak VP. [Postoperative complications and mortality in peptic ulcer of the duodenum and stomach]. Klin Khir. 1994;(10):41-3. Russian. PubMed PMID: 7602907.

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