GTPL5846
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531170

CAS#: 83797-69-7

Description: GTPL5846 increases chemotaxis of polymorphonuclear leukocytes and macrophages and stimulates production of pro-inflammatory cytokines.

Chemical Structure

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GTPL5846
CAS# 83797-69-7
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 531170
Name: GTPL5846
CAS#: 83797-69-7
Chemical Formula: C12H21N3O2
Exact Mass: 239.16
Molecular Weight: 239.319
Elemental Analysis: C, 60.23; H, 8.85; N, 17.56; O, 13.37

Price and Availability

Size Price Availability Quantity
100mg USD 750
200mg USD 1250
500mg USD 2250
1g USD 3450
2g USD 4950
5g USD 6950
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Synonym: GTPL5846; GTPL 5846; GTPL-5846.

IUPAC/Chemical Name: 6-(Octylamino)-2,4(1H,3H)-pyrimidinedione

InChi Key: PFSWASUQURIOOR-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H21N3O2/c1-2-3-4-5-6-7-8-13-10-9-11(16)15-12(17)14-10/h9H,2-8H2,1H3,(H3,13,14,15,16,17)

SMILES Code: O=C1NC(C=C(NCCCCCCCC)N1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: 6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM.
In vitro activity: Rather, 6-OAU significantly suppressed mRNA expression of IL-6 (1 μM, p = 0.019) and IL-12 p40 (0.1 μM, p = 0.02) (Fig. 1a). Reference: J Neuroinflammation. 2017 Oct 3;14(1):198. https://pubmed.ncbi.nlm.nih.gov/28974234/
In vivo activity: The in vivo studies showed that both treatments via oral route augmented resistance to Brucella infection but more pronounced with 6-OAU as observed with reduced bacterial proliferation in spleens and livers. At 7 d post-treatment and 14 d post-infection, 6-OAU-treated mice displayed reduced IFN-γ serum level. Reference: Microb Pathog. 2021 Sep;158:105079. https://pubmed.ncbi.nlm.nih.gov/34245824/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.0 125.36

Preparing Stock Solutions

The following data is based on the product molecular weight 239.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Wei L, Tokizane K, Konishi H, Yu HR, Kiyama H. Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia. J Neuroinflammation. 2017 Oct 3;14(1):198. doi: 10.1186/s12974-017-0970-y. PMID: 28974234; PMCID: PMC5627487. 2. Suzuki M, Takaishi S, Nagasaki M, Onozawa Y, Iino I, Maeda H, Komai T, Oda T. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. doi: 10.1074/jbc.M112.420042. Epub 2013 Feb 28. PMID: 23449982; PMCID: PMC3624448. 3. Reyes AWB, Kim H, Huy TXN, Vu SH, Nguyen TT, Kang CK, Min W, Lee HJ, Lee JH, Kim S. Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microb Pathog. 2021 Sep;158:105079. doi: 10.1016/j.micpath.2021.105079. Epub 2021 Jul 8. PMID: 34245824.
In vitro protocol: 1. Wei L, Tokizane K, Konishi H, Yu HR, Kiyama H. Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia. J Neuroinflammation. 2017 Oct 3;14(1):198. doi: 10.1186/s12974-017-0970-y. PMID: 28974234; PMCID: PMC5627487. 2. Suzuki M, Takaishi S, Nagasaki M, Onozawa Y, Iino I, Maeda H, Komai T, Oda T. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. doi: 10.1074/jbc.M112.420042. Epub 2013 Feb 28. PMID: 23449982; PMCID: PMC3624448.
In vivo protocol: 1. Reyes AWB, Kim H, Huy TXN, Vu SH, Nguyen TT, Kang CK, Min W, Lee HJ, Lee JH, Kim S. Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microb Pathog. 2021 Sep;158:105079. doi: 10.1016/j.micpath.2021.105079. Epub 2021 Jul 8. PMID: 34245824.

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