Fluensulfone | CAS#318290-98-1 | nematicide

Fluensulfone
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531140

CAS#: 318290-98-1

Description: Fluensulfone is a new nematicide for chemical control of plant parasitic nematodes.

Chemical Structure

Fluensulfone

CAS# 318290-98-1

Instruction

Theoretical Analysis

MedKoo Cat#: 531140
Name: Fluensulfone
CAS#: 318290-98-1
Chemical Formula: C7H5ClF3NO2S2
Exact Mass: 290.94
Molecular Weight: 291.687
Elemental Analysis: C, 28.82; H, 1.73; Cl, 12.15; F, 19.54; N, 4.80; O, 10.97; S, 21.98

Price and Availability

Size	Price	Availability	Quantity
1g	USD 2950
2g	USD 4250
5g	USD 7950
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Fluensulfone

IUPAC/Chemical Name: 5-chloro-2-(3,4,4-trifluorobut-3-ene-1-sulfonyl)-1,3-thiazole

InChi Key: XSNMWAPKHUGZGQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H5ClF3NO2S2/c8-5-3-12-7(15-5)16(13,14)2-1-4(9)6(10)11/h3H,1-2H2

SMILES Code: O=S(CC/C(F)=C(F)\F)(C1=NC=C(Cl)S1)=O

Appearance: Yellow to brown oil

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 291.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Grabau ZJ, Noling JW, Navia Gine PA. Fluensulfone and 1,3-dichloroprene for plant-parasitic nematode management in potato production. J Nematol. 2019;51:1-12. doi: 10.21307/jofnem-2019-038. PMID: 31339250; PMCID: PMC6916143.

2: Morris KA, Li X, Langston DB, Davis RF, Timper P, Grey TL. Fluensulfone sorption and mobility as affected by soil type. Pest Manag Sci. 2018 Feb;74(2):430-437. doi: 10.1002/ps.4724. Epub 2017 Oct 18. PMID: 28869328.

3: Oka Y. Sensitivity to fluensulfone of inactivated Meloidogyne spp. second- stage juveniles. Pest Manag Sci. 2020 Jul;76(7):2379-2387. doi: 10.1002/ps.5774. Epub 2020 Feb 18. PMID: 32027087.

4: Kearn J, Ludlow E, Dillon J, O'Connor V, Holden-Dye L. Fluensulfone is a nematicide with a mode of action distinct from anticholinesterases and macrocyclic lactones. Pestic Biochem Physiol. 2014 Feb;109:44-57. doi: 10.1016/j.pestbp.2014.01.004. Epub 2014 Jan 31. PMID: 24581383.

5: Hada A, Singh D, Venkata Satyanarayana KKV, Chatterjee M, Phani V, Rao U. Effect of fluensulfone on different functional genes of root-knot nematode Meloidogyne incognita. J Nematol. 2021 Aug 17;53:e2021-73. doi: 10.21307/jofnem-2021-073. PMID: 34414375; PMCID: PMC8371937.

6: Ploeg A, Stoddard S, Becker JO. Control of Meloidogyne incognita in sweetpotato with fluensulfone. J Nematol. 2019;51:1-8. doi: 10.21307/jofnem-2019-018. PMID: 31088030; PMCID: PMC6929636.

7: Shirley AM, Noe JP, Nyczepir AP, Brannen PM, Shirley BJ, Jagdale GB. Effect of spirotetramat and fluensulfone on population densities of Mesocriconema xenoplax and Meloidogyne incognita on peach. J Nematol. 2019;51:1-10. doi: 10.21307/jofnem-2019-012. PMID: 31088024; PMCID: PMC6929638.

8: Morris KA, Langston DB, Dickson DW, Davis RF, Timper P, Noe JP. Efficacy of Fluensulfone in a Tomato-Cucumber Double Cropping System. J Nematol. 2015 Dec;47(4):310-5. PMID: 26941459; PMCID: PMC4755705.

9: Oka Y, Saroya Y. Effect of fluensulfone and fluopyram on the mobility and infection of second-stage juveniles of Meloidogyne incognita and M. javanica. Pest Manag Sci. 2019 Aug;75(8):2095-2106. doi: 10.1002/ps.5399. Epub 2019 Apr 5. PMID: 30843368.

10: Zhang JJ, Cao W, Xi P, Li L, Qiao S, Luo H, Zhang J, Liu X, Du N. S-Glycosylation of Fluensulfone in Tomatoes: An Important Way of Fluensulfone Metabolism. J Agric Food Chem. 2021 Nov 10;69(44):12974-12984. doi: 10.1021/acs.jafc.1c04725. Epub 2021 Nov 1. PMID: 34723494.

11: Oka Y. Nematicidal activity of fluensulfone against some migratory nematodes under laboratory conditions. Pest Manag Sci. 2014 Dec;70(12):1850-8. doi: 10.1002/ps.3730. Epub 2014 Feb 25. PMID: 24452922.

12: Grabau ZJ, Liu C, Navia Gine PA. Belonolaimus longicaudatus management using metam potassium and fluensulfone in potato. J Nematol. 2023 Jul 6;55(1):20230028. doi: 10.2478/jofnem-2023-0028. PMID: 37426724; PMCID: PMC10324121.

13: Morris KA, Langston DB, Davis RF, Noe JP, Dickson DW, Timper P. Efficacy of Various Application Methods of Fluensulfone for Managing Root-knot Nematodes in Vegetables. J Nematol. 2016 Jun;48(2):65-71. doi: 10.21307/jofnem-2017-010. PMID: 27418698; PMCID: PMC4930317.

14: Feist E, Kearn J, Gaihre Y, O'Connor V, Holden-Dye L. The distinct profiles of the inhibitory effects of fluensulfone, abamectin, aldicarb and fluopyram on Globodera pallida hatching. Pestic Biochem Physiol. 2020 May;165:104541. doi: 10.1016/j.pestbp.2020.02.007. Epub 2020 Feb 5. PMID: 32359561.

15: Norshie PM, Grove IG, Back MA. Field evaluation of the nematicide fluensulfone for control of the potato cyst nematode Globodera pallida. Pest Manag Sci. 2016 Oct;72(10):2001-7. doi: 10.1002/ps.4329. Epub 2016 Jul 4. PMID: 27241192; PMCID: PMC5129520.

16: Oka Y, Shuker S, Tkachi N. Influence of soil environments on nematicidal activity of fluensulfone against Meloidogyne javanica. Pest Manag Sci. 2013 Nov;69(11):1225-34. doi: 10.1002/ps.3487. Epub 2013 Mar 1. PMID: 23456999.

17: Oka Y, Shuker S, Tkachi N. Systemic nematicidal activity of fluensulfone against the root-knot nematode Meloidogyne incognita on pepper. Pest Manag Sci. 2012 Feb;68(2):268-75. doi: 10.1002/ps.2256. Epub 2011 Aug 12. PMID: 21842527.

18: Zuo W, Wu Z, Xiong H, Zhou H, Wang C, Li J. Simultaneous determination of the nematicide fluensulfone and its two major metabolites in soils by ultra-high performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2023 Aug 2;1702:464096. doi: 10.1016/j.chroma.2023.464096. Epub 2023 May 23. PMID: 37245354.

19: Cao X, Yang H, Liu C, Zhang R, Maienfisch P, Xu X. Bioisosterism and Scaffold Hopping in Modern Nematicide Research. J Agric Food Chem. 2022 Sep 14;70(36):11042-11055. doi: 10.1021/acs.jafc.2c00785. Epub 2022 May 12. PMID: 35549340.

20: Strupp C, Bomann W, Cohen SM, Weber K. Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors. II: Additional Mechanistic Studies. Toxicol Sci. 2016 Dec;154(2):296-308. doi: 10.1093/toxsci/kfw168. Epub 2016 Sep 7. PMID: 27605420.

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