Ro 244736

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526942

CAS#: 125030-71-9

Description: Ro 24-4736 is a platelet activating factor inhibitor potentially for the treatment of asthma. Ro-24-4736 protects the rat kidney from ischemic injury.

Chemical Structure

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Ro 244736
CAS# 125030-71-9
Instruction

Theoretical Analysis

MedKoo Cat#: 526942
Name: Ro 244736
CAS#: 125030-71-9
Chemical Formula: C31H20ClN5OS
Exact Mass: 545.11
Molecular Weight: 546.045
Elemental Analysis: C, 68.19; H, 3.69; Cl, 6.49; N, 12.83; O, 2.93; S, 5.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Ro 24-4736; Ro24-4736; Ro-24-4736; Ro 244736; Ro244736; Ro-244736.

IUPAC/Chemical Name: 5-(3-(4-(2-Chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-2-yl)-2-propynyl)phenanthridin-6(5H)-one

InChi Key: MPMZSZMDCRPSRF-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H20ClN5OS/c1-19-34-35-28-18-33-29(24-13-4-6-14-26(24)32)25-17-20(39-31(25)37(19)28)9-8-16-36-27-15-7-5-11-22(27)21-10-2-3-12-23(21)30(36)38/h2-7,10-15,17H,16,18H2,1H3

SMILES Code: O=C1N(CC#CC(S2)=CC3=C2N4C(CN=C3C5=CC=CC=C5Cl)=NN=C4C)C6=CC=CC=C6C7=C1C=CC=C7

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 546.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jackson JR, Bolognese B, Mangar CA, Hubbard WC, Marshall LA, Winkler JD. The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis. Biochim Biophys Acta. 1998 May 20;1392(1):145-52. PubMed PMID: 9593866.

2: Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010.

3: Kelly KJ, Tolkoff-Rubin NE, Rubin RH, Williams WW Jr, Meehan SM, Meschter CL, Christenson JG, Bonventre JV. An oral platelet-activating factor antagonist, Ro-24-4736, protects the rat kidney from ischemic injury. Am J Physiol. 1996 Nov;271(5 Pt 2):F1061-7. PubMed PMID: 8946001.

4: Zellweger R, Ayala A, Schmand JF, Morrison MH, Chaudry IH. PAF-antagonist administration after hemorrhage-resuscitation prevents splenocyte immunodepression. J Surg Res. 1995 Sep;59(3):366-70. PubMed PMID: 7643595.

5: Elder CA, Modi MW. Interspecies scaling of a thienodiazepine platelet-activating factor receptor antagonist. Drug Metab Dispos. 1995 Jul;23(7):776-8. PubMed PMID: 7587967.

6: Wasserman MA, Welton AF, Renzetti LM. Synergism exhibited by LTD4 and PAF receptor antagonists in decreasing antigen-induced airway microvascular leakage. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:271-3. PubMed PMID: 7732851.

7: Welton AF, O'Donnell M, Renzetti L, Simko B, Tocker J, Cashin C, Newbold P, Wasserman MA. Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation. Ann N Y Acad Sci. 1994 Nov 15;744:274-88. PubMed PMID: 7825850.

8: Wright DT, Adler KB, Akley NJ, Dailey LA, Friedman M. Ozone stimulates release of platelet activating factor and activates phospholipases in guinea pig tracheal epithelial cells in primary culture. Toxicol Appl Pharmacol. 1994 Jul;127(1):27-36. PubMed PMID: 8048050.

9: Thompson WA, Coyle S, Van Zee K, Oldenburg H, Trousdale R, Rogy M, Felsen D, Moldawer L, Lowry SF. The metabolic effects of platelet-activating factor antagonism in endotoxemic man. Arch Surg. 1994 Jan;129(1):72-9. PubMed PMID: 8279943.

10: Anastasi EM, Williams TH, Sasso GJ, Chang D, Liberato DJ, Loh AC. Disposition and metabolism of Ro 24-4736 in the rat. Life Sci. 1994;54(26):PL483-90. PubMed PMID: 8208055.

11: Thomas TK, Chesonis RS, Schmolze D, Symington J, Harbison ML, Walser A, Will PC. Differential antagonism of platelet activating factor-induced neutrophilia and gastric hemorrhage in the rat. Agents Actions. 1993;39 Spec No:C195-7. PubMed PMID: 8273566.

12: Crowley HJ, Yaremko B, Selig WM, Janero DR, Burghardt C, Welton AF, O'Donnell M. Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736. J Pharmacol Exp Ther. 1991 Oct;259(1):78-85. PubMed PMID: 1656030.

13: O'Donnell M. Effects of Ro 24-4736 in antagonizing the platelet and bronchoconstrictor responses to PAF. Ann N Y Acad Sci. 1991;629:416-8. PubMed PMID: 1659287.