Tetridamine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328304

CAS#: 17289-49-5

Description: Tetridamine, also known as POLI-67, is an analgesic and anti-inflammatory drug used to treat vaginitis.

Chemical Structure

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Tetridamine
CAS# 17289-49-5
Instruction

Theoretical Analysis

MedKoo Cat#: 328304
Name: Tetridamine
CAS#: 17289-49-5
Chemical Formula: C9H15N3
Exact Mass: 165.13
Molecular Weight: 165.240
Elemental Analysis: C, 65.42; H, 9.15; N, 25.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Tetridamine; POLI-67; POLI 67; POLI67

IUPAC/Chemical Name: N,2-dimethyl-4,5,6,7-tetrahydro-2H-indazol-3-amine

InChi Key: NKDJNEGDJVXHKM-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H15N3/c1-10-9-7-5-3-4-6-8(7)11-12(9)2/h10H,3-6H2,1-2H3

SMILES Code: CNC1=C2CCCCC2=NN1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 165.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Manzardo S, Girardello R, Pinzetta A, Coppi G, De Aloysio D. Activity and tolerability of tetridamine vaginal lavage in rats and women. Boll Chim Farm. 1992 Mar;131(3):113-6. PubMed PMID: 1418890.

2: Ballesterosé S, Ramón MF, Martínez-Arrieta R. Oral tetridamine exposures. Clin Toxicol (Phila). 2009 Feb;47(2):150-2. doi: 10.1080/15563650801938688. PubMed PMID: 18608303.

3: Pugliares S, Jacobellis M. [Tetridamine in the therapy of bacterial vaginosis]. Minerva Ginecol. 1991 May;43(5):245-51. Review. Italian. PubMed PMID: 1881569.

4: Massaroli G, Cellari C, Coerezza M, Scuri R. [Absorption, metabolism and excretion of 2-methyl-3-methylamino-4,5,6,7-tetrahydroindazole (tetridamine) in the rat]. Boll Chim Farm. 1972 Nov;111(11):649-57. Italian. PubMed PMID: 4655669.